Titre du document / Document title

Effects of oleoyl-estrone with dexfenfluramine, sibutramine or phentermine on overweight rats

Auteur(s) / Author(s)

FERRER-LORENTE Raquel ⁽¹⁾ ; CABOT Cristina ⁽¹⁾ ; FERNANDEZ-LOPEZ José-Antonio ⁽¹⁾ ; REMESAR Xavier ⁽¹⁾ ; ALEMANY Maria ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, Av. Diagonal, 645, 08028 Barcelona, ESPAGNE

Résumé / Abstract

We studied the combination of oleoyl-estrone with either dexfenfluramine, sibutramine or phentermine in overweight male rats treated for 10 days in order to determine whether they shared a mechanism of action. Oleoyl-estrone, dexfenfluramine and sibutramine decreased body weight and energy (essentially lipids); losses were higher when combined with oleoyl-estrone. Glycemia was maintained except under phentermine; oleoyl-estrone induced decreases in triacylglycerols, cholesterol, insulin and HOMA (homeostasis model assessment). Combination of oleoyl-estrone and sibutramine resulted in the loss of up to 29% body energy in 10 days. Energy expenditure was maintained. The effects of oleoyl-estrone and dexfenfluramine or sibutramine on appetite were substantially additive. All oleoyl-estrone-treated rats showed increased insulin sensitivity. In conclusion, combined treatment of overweight rats with oleoyl-estrone and sibutramine or dexfenfluramine results in a dramatic loss of weight and fat, whilst maintaining circulating energy homoeostasis.

Revue / Journal Title

European journal of pharmacology   ISSN 0014-2999   CODEN EJPHAZ 

Source / Source

2005, vol. 513, n^o3, pp. 243-248 [6 page(s) (article)] (34 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1967) (Revue)

Mots-clés anglais / English Keywords

Neurotransmitter ; Catecholamine ; Nutrition disorder ; Serotonin ; Norepinephrine ; Reuptake inhibitor ; Amphetamine derivatives ; Vertebrata ; Mammalia ; Rodentia ; Nutritional status ; Anorectic ; Obesity ; Rat ; Animal ; Overweight ; Phentermine ; Sibutramine ; Dexfenfluramine ; Estrone ;

Mots-clés français / French Keywords

Neurotransmetteur ; Catécholamine ; Trouble nutrition ; Sérotonine ; Noradrénaline ; Inhibiteur recapture ; Amphétamine dérivé ; Vertebrata ; Mammalia ; Rodentia ; Etat nutritionnel ; Anorexigène ; Obésité ; Rat ; Animal ; Surcharge pondérale ; Phentermine ; Sibutramine ; Dexfenfluramine ; Estrone ;

Mots-clés espagnols / Spanish Keywords

Neurotransmisor ; Catecolamina ; Trastorno nutricíon ; Serotonina ; Noradrenalina ; Inhibidor recaptura ; Amfetamina derivado ; Vertebrata ; Mammalia ; Rodentia ; Estado nutricional ; Anorexígeno ; Obesidad ; Rata ; Animal ; Sobrecarga ponderal ; Fentermina ; Sibutramina ; Dexfenfluramina ; Estrona ;

Mots-clés d'auteur / Author Keywords

Obesity ; Overweight ; Energy balance ; Oleoyl-estrone ; Dexfenfluramine ; Sibutramine ; Phentermine ;

Localisation / Location

INIST-CNRS, Cote INIST : 13322, 35400012539053.0090