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Titre du document / Document title

Acetato de megestrol en pacientes con síndrome de caquexia-anorexia por neoplasia avanzada = Megestrol acetate in patient with caquexia-anorexia syndrome caused by advanced neoplasia

Auteur(s) / Author(s)


Résumé / Abstract

Introduction: the caquexia-anorexia syndrome is present in almost 70% of the patients with terminal neoplasia, including it can be present in earlier stages. It has a very big repercussion as well in the physical as psychical condition. It was observed that the megestrol acetate produces a stimulus of the appetite and an increase of the weight in patients with anorexia and/or caquexia in patients with different types of cancer. Method: it was carried out an observational study to evaluate the effect of megestrol acetate using several parameters to evaluate the nutritional conditions. The principal variables were: increase of weight, subjective feeling of increase of weight, using a visual analogical scale, the body mass index and the weight referred to desirable weight. Results: it has been included a total of 103 patients. The mean age was 62.6 years. Seventy of the patients were male and 33 were women. The patients were treated with diary doses of megestrol acetate between 480 and 320 mg/day. The duration of the treatment was of 4 months. It has been observed a significant increase of weight of 1.78 kg, already at the second month of treatment with megestrol acetate. This increase was of 2.85 kg (p< 0.001) at the 4 month of treatment. Th body mass index was also increased siginficatively as in the two months as in the four months of treatment with megestrol acetate (p<0.001). Referring to the subjective feeling of appetite, measured by an analogical scale, it was observed an improvement of the appetite feeling in 79.6% of the patients. Therefore, the feeling of asthenia, decreased in 61.1% of the evaluated patients, already in the first month of treatment. In all the efficacy parameters, there was performed correlation analysis, the results showed a positive correlation between all of them. Discussion: as a conclusion it can be establish that the treatment with megestrol acetate suppose a fast and significative improvement of the symptoms and signs in patients affected of caquexia-anorexia syndrome associated an advanced neoplasia.

Revue / Journal Title

Medicina paliativa    ISSN  1134-248X 

Source / Source

2002, vol. 9, no2, pp. 71-76 [6 page(s) (article)]

Langue / Language


Editeur / Publisher

Aràn, Madrid, ESPAGNE  (1994) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 27638, 35400012955432.0050

Nº notice refdoc (ud4) : 16732558

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