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Titre du document / Document title

Aplicaciones de anticuerpos monoclonales y productos de biotecnología en el tratamiento de las enfermedades inflamatorias crÓnicas = Applications of monoclonal antibodies and biotechnology products in the treatment of chronic inflammatory diseases

Auteur(s) / Author(s)


Résumé / Abstract

In recent years we have noticed the arrival of biological drugs for the treatment of rheumatoid arthritis (RA), Crohn's disease (CD), psoriasis, and other chronic inflammatory diseases. Those drugs are produced with biotechnology methods and are defined as biologicals because of they work on the immune system. Different cellular groups and inflammation mediators participate in the inflammatory process, all of them susceptible of a therapeutic approach; they are so-called biological targets. Inhibition of TNF and interleukina 1 (IL-1) has proven effective for the control of inflammation in diseases as RA or CD. At present we have two types of inhibitors of TNF, specific monoclonal antibodies (infliximab, adalimumab) and cellular receptors (etanercept) and an IL-1 inhibitor (anakinra). The use of TNF inhibitors has given rise to a substantial change in the treatment of RA and CD because of its effectiveness. Together with this beneficial effect, an increase of infections (some of them severe) has occurred, especially tuberculosis. Other side effects that can be considered infrequent include demyelinization, herat failure, blood dyscrasias and lymphomas, which means that a thorough knowledge of these drugs is necessary for their use. Other potential biological drugs still in investigational phase are mentioned.

Revue / Journal Title

Revista clinica espanola    ISSN  0014-2565 

Source / Source

2005, vol. 205, no3, pp. 127-136 [10 page(s) (article)]

Langue / Language


Editeur / Publisher

Elsevier, Barcelone, ESPAGNE  (1940) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 6447, 35400012598125.0080

Nº notice refdoc (ud4) : 16717324

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