Titre du document / Document title
The right ventricle in Fabry disease
Auteur(s) / Author(s)KAMPMANN C.
BAEHNER F. A.
WIETHOFF C. M.
Résumé / Abstract
Aim: Left ventricular (LV) hypertrophy is a common feature in Fabry disease-related progressive infiltrative hypertrophic cardiomyopathy and affects both men and women, but at different ages. To date, however, little is known about the role of right ventricular (RV) function in Fabry disease. Therefore, this study aimed to investigate the extent of RV involvement in patients with Fabry disease. Methods: Echocardiographic examination of the right and left ventricle was carried out in 129 patients (80 women and 49 men) with Fabry disease. Results: RV hypertrophy was present in 46 patients (35.7%). Of these patients, 13 showed signs of severely depressed right systolic function (tricuspid annulus movement <10 mm and a prolonged RV pre-ejection period/pulmonary ejection time ratio) and six patients showed additional severe depression of parameters of diastolic function (pseudo-normal or restrictive RV filling patterns). Those patients with RV hypertrophy and severely compromised systolic and diastolic function had the highest LV masses (92′11.7 g/m2.7
). Conclusion: RV involvement is common in Fabry disease and ultimately progresses to severe systolic and diastolic RV dysfunction. These findings might explain why patients with preserved LV function can develop clinical features such as reduced exercise capacity, organomegaly and lymphoedema.
Revue / Journal TitleActa paediatrica. Supplement
Source / Source
International Symposium on Lysosomal Storage Diseases No
2005, vol. 94, no
447 (133 p.) [Document : 4 p.] (bibl.: dissem.), [Notes: Papers and abstracts], pp. 15-18 [4 page(s) (article)]
Langue / Language
Editeur / Publisher
Blackwell, Oxford, ROYAUME-UNI
Mots-clés d'auteur / Author Keywords
Localisation / Location
INIST-CNRS, Cote INIST : 944 B, 35400012941978.0020
Nº notice refdoc (ud4) : 16677924