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Titre du document / Document title

Electroencephalography in the assessment of neuropsychiatric manifestations in antiphospholipid syndrome and systemic lupus erythematosus

Auteur(s) / Author(s)

LAMPROPOULOS Christos E. (1) ; KOUTROUMANIDIS Michael (1) ; REYNOLDS Piero P. M. (1) ; MANIDAKIS Ioannis (1) ; HUGHES Graham R. V. (1) ; D'CRUZ David P. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) St. Thomas' Hospital, London, ROYAUME-UNI

Résumé / Abstract

Objective. To describe the prevalence and clinical associations of abnormalities on electroencephalography (EEG) in patients with antiphospholipid syndrome (APS) and/or systemic lupus erythematosus (SLE) who have neuropsychiatric symptoms. Methods. The study group comprised 57 patients (age ≤50 years) with manifestations of neuropsychiatric illness. Patients with stroke, epilepsy, or other encephalopathies were excluded. Fourteen patients had APS, 24 patients were positive for antiphospholipid antibodies (aPL), and 19 patients had SLE without aPL. All patients underwent EEG and brain magnetic resonance imaging (MRI) while they were awake. Results. Abnormal EEG findings (showing mainly bitemporal slow activity) were recorded in 37 of 57 patients (65%). Abnormal EEG findings were observed in all patients with APS and in 17 of 24 aPL-positive patients (71%), compared with 6 of 19 patients with SLE (32%) (P < 0.001 and P < 0.05, respectively). There was an association between abnormal EEG findings and the frequency of aPL positivity (at least 2 positive results) (P = 0.002). Three EEG recordings showed potentially epileptiform activity. Results of brain MRI were abnormal in 18 (31.6%) of 57 patients: 8 in the APS group (57.1%), 7 in the aPL-positive group (29.2%), and 3 in the SLE group (15.8%). None of the patients with normal EEG findings had abnormal MRI results. Thus, brain MRI findings were normal in the majority of patients. Patients with abnormal EEG results were more likely to report memory problems (P < 0.001). Conclusion. Our findings suggest that EEG abnormalities are common and correlate with the presence of aPL even in the absence of brain abnormalities on MRI. EEG should be considered in aPL-positive patients with neuropsychiatric symptoms, because use of antiaggregants or anticoagulation may need to be considered.

Revue / Journal Title

Arthritis and rheumatism    ISSN  0004-3591   CODEN ARHEAW 

Source / Source

2005, vol. 52, no3, pp. 841-846 [6 page(s) (article)] (34 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken , NJ, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Connective tissue disease

;

Skin disease

;

Systemic disease

;

Vascular disease

;

Autoimmune disease

;

Hemopathy

;

Cardiovascular disease

;

Electrodiagnosis

;

Platelet

;

Antiphospholipid antibody syndrome

;

Electroencephalography

;

Systemic lupus erythematosus

;

Mots-clés français / French Keywords

Tissu conjonctif pathologie

;

Peau pathologie

;

Maladie système

;

Vaisseau sanguin pathologie

;

Maladie autoimmune

;

Hémopathie

;

Appareil circulatoire pathologie

;

Electrodiagnostic

;

Thrombocyte

;

Antiphospholipide syndrome

;

Electroencéphalographie

;

Lupus érythémateux disséminé

;

Mots-clés espagnols / Spanish Keywords

Tejido conjuntivo patología

;

Piel patología

;

Enfermedad sistémica

;

Vaso sanguíneo patología

;

Enfermedad autoinmune

;

Hemopatía

;

Aparato circulatorio patología

;

Electrodiagnóstico

;

Trombocito

;

Antifosfolípido síndrome

;

Electroencefalografía

;

Lupus eritematoso sistémico

;

Localisation / Location

INIST-CNRS, Cote INIST : 8711, 35400012713419.0200

Nº notice refdoc (ud4) : 16669598



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