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Titre du document / Document title

Anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux

Auteur(s) / Author(s)

LEE Keyong-Ho (1) ; CHOI Hye-Ran (2) ; KIM Chang-Han (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Kolon Central Research Park, Yongin, Kyunggi-do 449-912, COREE, REPUBLIQUE DE
(2) Animal Resource Research Center Konkuk University, 1 Hwayangn-dong, Kwangjin-ku, Seoul 143-701, COREE, REPUBLIQUE DE

Résumé / Abstract

Benincasa hispida in Korea was used mainly diabetes and diuresis diseases. This study was carried out to evaluate anti-angiogenic effect of the seed extract of Benincasa hispida Cogniaux. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor found in various tumors. In this study, we found that the seed extract of Benincasa hispida Cogniaux decreased bFGF-induced endothelial cell proliferation and tube formation in a dose-dependent manner. Besides, Benincasa hispida seed extract showed no cytotoxicity on HUVECs and normal fibroblast cells. Furthermore, the seed extract of Benincasa hispida showed a potent inhibitory effect on bFGF-induced angiogenesis in vivo. These results suggest that the seed extract of Benincasa hispida inhibits the proliferation of endothelial cells induced by bFGF, which may explain its anti-angiogenic properties.

Revue / Journal Title

Journal of ethnopharmacology    ISSN  0378-8741 

Source / Source

2005, vol. 97, no3, pp. 509-513 [5 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Cucurbitaceae

;

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Fibroblast growth factor

;

Angiogenesis

;

Benincasa hispida

;

Extract

;

Seeds

;

Antiangiogenic agent

;

Mots-clés français / French Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Cucurbitaceae

;

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Facteur croissance fibroblaste

;

Angiogenèse

;

Benincasa hispida

;

Extrait

;

Graine

;

Antiangiogénique

;

Mots-clés espagnols / Spanish Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Cucurbitaceae

;

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Factor crecimiento fibroblasto

;

Angiogénesis

;

Benincasa hispida

;

Extracto

;

Semillas

;

Antiangiogenico

;

Mots-clés d'auteur / Author Keywords

Benincasa hispida Cogniaux

;

Anti-angiogenesis

;

Basic fibroblast growth factor

;

Localisation / Location

INIST-CNRS, Cote INIST : 18028, 35400012500212.0150

Nº notice refdoc (ud4) : 16602737



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