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Titre du document / Document title

Identification of a new source of interference leached from polypropylene tubes in mass-selective analysis

Auteur(s) / Author(s)

XIA Yuan-Qing (1) ; PATEL Shefali (1) ; BAKHTIAR Ray (1) ; FRANKLIN Ronald B. (1) ; DOSS George A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey, ETATS-UNIS

Résumé / Abstract

An interference leached from polypropylene tubes was identified to be a sulfoxide oxidative product of didodecyl 3,3'-thiodipropionate (DDTDP) that is used to prevent oxidative degradation of synthetic polymers. A sulfone oxidative product of DDTDP leached from the polypropylene tubes was also observed. The interfering compounds were isolated by LC and characterized using time-of-flight mass spectrometry and NMR. Authentic sulfoxide and sulfone products of DDTDP were also prepared by reacting DDTDP with hydrogen peroxide reaching an unequivocal structural assignment. In conclusion, when analytes of interest are solubilized in predominantly organic solvents and kept in polypropylene containers, the possibility of contamination from leached chemicals should be taken into account.

Revue / Journal Title

Journal of the American Society for Mass Spectrometry    ISSN  1044-0305 

Source / Source

2005, vol. 16, no3, pp. 417-421 [5 page(s) (article)] (6 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1990) (Revue)

Mots-clés anglais / English Keywords

Time of flight method

;

Mass spectrometry MS/MS

;

Coupled method

;

HPLC chromatography

;

Plastic tube

;

Contamination

;

Container content interaction

;

Interference

;

Sulfoxide

;

Sulfone

;

Propylene polymer

;

Antioxidant

;

Additive

;

Degradation product

;

Chemical analysis

;

Mots-clés français / French Keywords

3,3p-Thiodipropionique acide ester didodécyle

;

Méthode temps vol

;

Spectrométrie masse tandem

;

Méthode couplée

;

Chromatographie HPLC

;

Tube plastique

;

Contamination

;

Interaction contenant contenu

;

Interférence

;

Sulfoxyde

;

Sulfone

;

Propène polymère

;

Antioxydant

;

Additif

;

Produit dégradation

;

Analyse chimique

;

Mots-clés espagnols / Spanish Keywords

Método tiempo vuelo

;

Espectrometría masa en tándem

;

Método acoplado

;

Cromatografía HPLC

;

Tubo plástico

;

Contaminación

;

Interacción continente contenido

;

Interferencia

;

Sulfóxido

;

Sulfona

;

Propeno polímero

;

Antioxidante

;

Aditivo

;

Producto degradación

;

Análisis químico

;

Localisation / Location

INIST-CNRS, Cote INIST : 22160, 35400012933892.0160

Nº notice refdoc (ud4) : 16578108



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