Titre du document / Document title

Incidence of venous thromboembolism in families with inherited thrombophilia

Auteur(s) / Author(s)

SIMIONI P. ⁽¹⁾ ; SANSON B.-J. ⁽²⁾ ; PRANDONI P. ⁽¹⁾ ; TORMENE D. ⁽¹⁾ ; FRIEDERICH P. W. ⁽²⁾ ; GIROLAMI B. ⁽¹⁾ ; GAVASSO S. ⁽¹⁾ ; HUISMAN M. V. ⁽³⁾ ; BÜLLER H. R. ⁽³⁾ ; TEN CATE J. W. ⁽³⁾ ; GIROLAMI A. ⁽¹⁾ ; PRINS M. H. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Medical and Surgical Sciences, University Hospital of Padua, ITALIE
⁽²⁾ Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, PAYS-BAS
⁽³⁾ Centre for Haemostasis, Thrombosis, Atherosclerosis, and Inflammation Research, Academic Medical Centre, Amsterdam, PAYS-BAS

Résumé / Abstract

The risk of spontaneous or risk-period related venous thromboembolism in family members of symptomatic carriers of antithrombin (AT), protein C (PC) or protein S (PS) defects, as well as of the Factor V Leiden mutation is still undefined. We performed a retrospective cohort study in family members (n = 793) of unselected patients with a documented venous thromboembolism and one of these deficiencies to make an estimate of this risk. The annual incidences of total and spontaneous venous thromboembolic events in carriers of AT, PC or PS defects (n = 181) were 1.01% and 0.40%, respectively, as compared to 0.10% and 0.04% in non-carriers. respectively (relative risks both 10.6). In carriers of Factor V Leiden (n = 224), the annual incidences of total and spontaneous venous thromboembolism were 0.28% and 0.11%, respectively, as compared to 0.09% and 0.04% in non-carriers, respectively (relative risks 2.8 and 2.5). Additional risk factors (immobilisation, surgery and trauma; oral contraceptive use: and pregnancy/ post-partum) increased the risk of thrombosis in carriers of AT, PC and PS defects as compared to non-carriers (relative risks 8.3. 6.4 and 8.2. respectively). Oral contraceptive use and pregnancy/ post-partum period increased the risk of thrombosis in carriers of Factor V Leiden to 3.3-fold and 4.2-fold, respectively, whereas other risk factors had only a minor effect. These data lend some support to the practice of screening family members of symptomatic carriers of a AT, PC and PS deficiency. For family members of symptomatic carriers of Factor V Leiden. screening does not seem to be justified except for women in fertile age.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

1999, vol. 81, n^o2, pp. 198-202 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Thrombosis ; Vein ; Thromboembolism ; Hypercoagulability ; Hereditary ; Incidence ; Epidemiology ; Cohort study ; Family study ; Netherlands ; Human ; Europe ; Cardiovascular disease ; Vascular disease ; Venous disease ; Hemopathy ; Coagulopathy ; Genetic disease ; Public health ;

Mots-clés français / French Keywords

Thrombose ; Veine ; Thromboembolie ; Hypercoagulabilité ; Héréditaire ; Incidence ; Epidémiologie ; Etude cohorte ; Etude familiale ; Pays Bas ; Homme ; Europe ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ; Veine pathologie ; Hémopathie ; Coagulopathie ; Maladie héréditaire ; Santé publique ;

Mots-clés espagnols / Spanish Keywords

Trombosis ; Vena ; Tromboembolia ; Hipercoagulabilidad ; Hereditario ; Incidencia ; Epidemiología ; Estudio cohorte ; Estudio familiar ; Holanda ; Hombre ; Europa ; Aparato circulatorio patología ; Vaso sanguíneo patología ; Vena patología ; Hemopatía ; Coagulopatía ; Enfermedad hereditaria ; Salud pública ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400007373831.0050