Titre du document / Document title
Hepatoprotective and antioxidant effects of Alnus japonica extracts on acetaminophen-induced hepatotoxicity in rats
Auteur(s) / Author(s)
SANG TAE KIM (1 2) ;
JUNG DO KIM (1) ;
SEUNG HEE AHN (1) ;
GU SEEK AHN (3) ;
YOUNG IK LEE (2) ;
YOONG SEOK JEONG (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biology, College of Liberal Arts and Science, Kyung Hee University, Seoul, COREE, REPUBLIQUE DE
(2) The Molecular Cell Biology Research Division, Korea Research Institute of Bioscience and Biotechnology, Korea Institute of Science and Technology, Taejon, COREE, REPUBLIQUE DE
(3) Department of Pathology, College of Orient Medicne, Kyung Hee University, Seoul, COREE, REPUBLIQUE DE
Résumé / Abstract
The stem bark of the Betulaceae plant Alnus japonica, which is indigenous to Korea, has been used as a popular folk medicine for hepatitis and cancer. In this study, the antioxidant activity of the crude extract and the hepatoprotective activities on acetaminophen (AAP)-induced toxicity in the rat liver were evaluated. We investigated the effect of the methanol (AJM) and solvent fracton of the stem bark of Alnus japonica (AJ) on AAP-induced hepatotoxicity in rats. In rat hepatocyte culture, pretreatment with AJM (50, 100, 150 and 200 μg/ml) significantly decreased the cytotoxicity of AAP in a dose-dependent manner. The pretreated with EtOAc and BuOH fraction led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation, both superoxide dismutase and catalase prevent the hepatotoxicity by AAP in the treatment of A. japonica fraction. We conclude that AJ is an important antioxidant in AAP-induced live hepatotoxicity and that extract of AJM plays a hepatoprotective effects in the against AAP-induced cytotoxicity in cultured rat hepatocytes in vitro. Pending more evaluation for safety and efficacy, AJ can potentially be used in mitigating AAP-induced hepatotoxicity.
Revue / Journal Title
PTR. Phytotherapy research
ISSN
0951-418X
Source / Source
2004, vol. 18, n
o12, pp. 971-975 [5 page(s) (article)] (20 ref.)
Langue / Language
Anglais
Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI
(1987)
(Revue)
Mots-clés anglais / English Keywords
Digestive system ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Betulaceae ;
Analgesic ;
Antipyretic ;
Plant origin ;
Medicinal plant ;
Pharmacognosy ;
Cytotoxicity ;
Radical scavenger ;
Free radical ;
Rat ;
Animal ;
Liver ;
Toxicity ;
Extract ;
Alnus ;
Antioxidant ;
Hepatoprotector ;
Paracetamol ;
Mots-clés français / French Keywords
Appareil digestif ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Betulaceae ;
Analgésique ;
Antipyrétique ;
Origine végétale ;
Plante médicinale ;
Pharmacognosie ;
Cytotoxicité ;
Intercepteur radical ;
Radical libre ;
Rat ;
Animal ;
Foie ;
Toxicité ;
Extrait ;
Alnus ;
Antioxydant ;
Hépatoprotecteur ;
Paracétamol ;
Mots-clés espagnols / Spanish Keywords
Aparato digestivo ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Betulaceae ;
Analgésico ;
Antipirético ;
Origen vegetal ;
Planta medicinal ;
Farmacognosia ;
Citotoxicidad ;
Interceptor radical ;
Radical libre ;
Rata ;
Animal ;
Hígado ;
Toxicidad ;
Extracto ;
Alnus ;
Antioxidante ;
Hepatoprotector ;
Paracetamol ;
Mots-clés d'auteur / Author Keywords
hepatoprotective ;
antioxidant ;
free radical scavenger ;
Alnus japonica ;
acetaminophen ;
cytotoxicity ;
Localisation / Location
INIST-CNRS, Cote INIST : 21695, 35400012673738.0040
Nº notice refdoc (ud4) : 16480039
