Titre du document / Document title

Clobetasol propionate shampoo 0.05% and calcipotriol solution 0.005%: A randomized comparison of efficacy and safety in subjects with scalp psoriasis

Auteur(s) / Author(s)

REYGAGNE P. ⁽¹⁾ ; MROWIETZ U. ⁽²⁾ ; DECROIX J. ; DE WAARD-VAN DER SPEK F. B. ⁽³⁾ ; OLMOS ACEBES L. ⁽⁴⁾ ; FIGUEIREDO A. ⁽⁵⁾ ; CAPUTO R. ⁽⁶⁾ ; PONCET M. ⁽⁷⁾ ; ARSONNAUD S. ⁽⁸⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Centre Sabouraud, Paris, FRANCE
⁽²⁾ Department of Dermatology, University of Kiel, Kiel, ALLEMAGNE
⁽³⁾ Erasmus MC, Rotterdam, PAYS-BAS
⁽⁴⁾ Hospital Clinico San Carlos, Madrid, ESPAGNE
⁽⁵⁾ Clinica de Dermatologia, Coimbra, PORTUGAL
⁽⁶⁾ Universita degli Studi di Milano, Milan, ITALIE
⁽⁷⁾ Galderma, Sophia-Antipolis, FRANCE
⁽⁸⁾ Galderma, Cranbury, NJ, ETATS-UNIS

Résumé / Abstract

Background: Scalp involvement in psoriatic patients represents a common issue. Treatment of the hairy skin requires adequate pharmaceutical formulations; hence, a new specific shampoo formulation of clobetasol propionate 0.05% was developed by Galderma R&D, Inc. Methods: For this multicenter, randomized, investigator-masked, parallel group study, 151 subjects with moderate to severe scalp psoriasis were randomized to 4 weeks of treatment with clobetasol propionate shampoo or calcipotriol solution. Results: Clobetasol propionate demonstrated significantly superior efficacy to calcipotriol solution (total severity score: mean difference 0.51, 95% CI 0.05-0.97, p=0.028; global severity score: mean difference 0.43, 95% CI 0.08-0.78, p=0.016). Adverse events were more common in the calcipotriol group than in the clobetasol propionate shampoo group. Telangiectasia and skin atrophy did not differ significantly between treatments; however, a burning sensation was significantly more common in the calcipotriol solution group. Conclusions: Short contact therapy of scalp psoriasis with this new shampoo formulation of clobetasol propionate was significantly more effective and better tolerated than calcipotriol solution for the treatment of scalp psoriasis.

Revue / Journal Title

Journal of dermatological treatment   ISSN 0954-6634 

Source / Source

2005, vol. 16, n^o1, pp. 31-36 [6 page(s) (article)] (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Oslo, NORVEGE  (1989) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; Vitamin D ; Analog ; Corticosteroid ; Shampoo ; Scalp ; Colecalciferol ; Antiinflammatory agent ; Psoriasis ; Human ; Chemotherapy ; Toxicity ; Comparative study ; Randomization ; Calcipotriol ; Clobetasol propionate ;

Mots-clés français / French Keywords

Peau pathologie ; Vitamine D ; Analogue ; Corticostéroïde ; Shampooing ; Cuir chevelu ; Colécalciférol ; Antiinflammatoire ; Psoriasis ; Homme ; Chimiothérapie ; Toxicité ; Etude comparative ; Randomisation ; Calcipotriol ; Clobétasol propionate ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Vitamina D ; Análogo ; Corticoesteroide ; Champú ; Cuero cabelludo ; Colecalciferol ; Antiinflamatorio ; Psoriasis ; Hombre ; Quimioterapia ; Toxicidad ; Estudio comparativo ; Aleatorización ; Calcipotriol ; Clobetasol propionato ;

Mots-clés d'auteur / Author Keywords

Calcipotriol gel ; Clobetasol propionate shampoo ; Global assessment of improvement ; Global severity score ; Scalp psoriasis ;

Localisation / Location

INIST-CNRS, Cote INIST : 22488, 35400012668563.0060