Titre du document / Document title

Carisoprodol intoxications and serotonergic features

Auteur(s) / Author(s)

BRAMNESS Jørgen G. ⁽¹⁾ ; MØRLAND Jørg ⁽¹⁾ ; SØRLID Hanne Kristin ⁽²⁾ ; RUDBERG Nina ⁽³⁾ ; JACOBSEN Dag ⁽⁴⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Forensic Toxicology and Drug Abuse, Norwegian Institute of Public Health, Oslo, NORVEGE
⁽²⁾ Department for Poisons Information, Directorate for Health and Social Affairs, Oslo, NORVEGE
⁽³⁾ Clinical Chemistry Department, Ullevaal University Hospital, Oslo, NORVEGE
⁽⁴⁾ Division of Medicine, Ullevaal University Hospital, Oslo, NORVEGE

Résumé / Abstract

The symptoms and signs of carisoprodol intoxications do not resemble those caused by its metabolite meprobamate. Meprobamate most probably produces its effects through the GABAergic neurotransmitter system. The signs and symptoms of carisoprodol intoxications, however, are not easily explained by interaction with this neurotransmitter system. In the present study, four cases of carisoprodol intoxications are presented with emphasis on the presence of serotonergic signs and symptoms. All four cases fulfilled three different sets of criteria for the diagnosis of serotonin syndrome. These findings could indicate that an increased serotonin level in the central nervous system could explain some of the symptoms and signs of carisoprodol intoxications. This may have implications for the clinical evaluation and treatment of such intoxications. Since few laboratories routinely screen for carisoprodol it is important to keep this drug in mind when encountering intoxications displaying serotonergic symptoms.

Revue / Journal Title

Journal of toxicology. Clinical toxicology   ISSN 0731-3810 

Source / Source

2005, vol. 43, n^o1, pp. 39-45 [7 page(s) (article)] (42 ref.)

Langue / Language

Anglais

Editeur / Publisher

Dekker, Monticello, NY, ETATS-UNIS  (1982-2004) (Revue)

Mots-clés anglais / English Keywords

Organic carbamate ; Serotonin syndrome ; Human ; Toxicity ; Drug intoxication ; Muscle relaxant ; Carisoprodol ;

Mots-clés français / French Keywords

Carbamate organique ; Sérotoninergique syndrome ; Homme ; Toxicité ; Intoxication médicamenteuse ; Myorelaxant ; Carisoprodol ;

Mots-clés espagnols / Spanish Keywords

Carbamato orgánico ; Serotoninérgico síndrome ; Hombre ; Toxicidad ; Intoxicación medicamentosa ; Relajante muscular ; Carisoprodol ;

Localisation / Location

INIST-CNRS, Cote INIST : 14107 A, 35400012587870.0070