Titre du document / Document title

Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects

Auteur(s) / Author(s)

NAKATANI Kaname ; NOMA Katsura ; NISHIOKA Junji ; KASAI Yasunari ; MORIOKA Kohei ; KATSUKI Akira ; HORI Yasuko ; YANO Yutaka ; SUMIDA Yasuhiro ; WADA Hideo ; NOBORI Tsutomu ;

Résumé / Abstract

Adiponectin is an adipocyte-secreted protein that is known to modulate insulin sensitivity and glucose homeostasis. A number of genetic variations have been studied. Among them, two single-nucleotide polymorphisms (SNP45T>G, SNP276G>T) showed an association with type 2 diabetes in the Japanese population. In this study, we examined the association between these SNPs and risk factors of type 2 diabetes in 194 non-diabetic Japanese subjects. SNP45 was associated with insulin sensitivity (determined by HOMA-IR, p=0.046) and obesity (body mass index; BMI, p=0.043). SNP276 showed a stronger association with HOMA-IR (p=0.018) and BMI (p=0.017). However, neither SNP had an association with insulin secretion (insulinogenic index) and plasma lipid levels. Moreover, a linkage disequilibrium was observed between SNP45 and SNP276. Carriers with SNP45G-SNP276G haplotype had higher BMI (p=0.034) and carriers with SNP45T-SNP276T haplotype had lower BMI (p=0.005) and HOMA-IR (p=0.037). Adiponectin gene variations showed an association with obesity and insulin sensitivity, and adiponectin genotypes may predict the increasing risk for type 2 diabetes in non-diabetic subjects.

Revue / Journal Title

International journal of molecular medicine   ISSN 1107-3756 

Source / Source

2005, vol. 15, n^o1, pp. 173-177 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

D.A. Spandidos, Athens, GRECE  (1998) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 27038, 35400012601184.0250