Titre du document / Document title

Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK

Auteur(s) / Author(s)

MILITAO G. C. G. ; ALBUQUERQUE M. R. J. R. ; PESSOA O. D. L. ; PESSOA C. ; MORAES M. E. A. ; DE MORAES M. O. ; COSTA-LOTUFO L. V. ;

Résumé / Abstract

The present study evaluated the cytotoxic activity of nepetin and quercetin-3-O-glucoside, compounds isolated from the aerial parts of Eupatorium ballotaefolium. The antimitotic activity was determined as the ability to inhibit sea urchin eggs development and five tumor cells lines growth. Moreover, the activities of these compounds were compared to quercetin in the same models. Nepetin inhibited the proliferation of the five tumor cell lines, once quercetin-3-O-glucoside did not present any activity even at the highest tested concentration and quercetin only inhibited proliferation of the B16 cell line. On the sea urchin assay, nepetin and quercetin induced a dose-dependent inhibition on egg development, while quercetin-3-O-glucoside did not modify normal egg cleavage, even at the highest tested concentration (100 μg/ml).

Revue / Journal Title

Pharmazie    ISSN  0031-7144   CODEN PHARAT 

Source / Source

2004, vol. 59, n^o12, pp. 965-966 [2 page(s) (article)]

Langue / Language

Anglais
Revue : Allemand

Editeur / Publisher

Govi, Eschborn, ALLEMAGNE  (1946) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 3582, 35400012283553.0140