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Titre du document / Document title

Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol

Auteur(s) / Author(s)

OSAKABE N. (1) ; SANBONGI C. (1) ; YAMAGISHI M. (1) ; TAKIZAWA T. (1) ; OSAWA T. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Functional Food Research and Development Laboratories, Meiji Seika Kaisha, Ltd., 5-3-1, Chiyoda, Sakadoshi, Saitama 350-0289, JAPON
(2) Department of Applied Biological Science, Nagoya University, Chikusa, Nagoya, Aichi 464-8601, JAPON

Résumé / Abstract

The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, α-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/ kg) were orally administerted to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.

Revue / Journal Title

Bioscience, biotechnology, and biochemistry    ISSN  0916-8451 

Source / Source

1998, vol. 62, no8, pp. 1535-1538 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Japan Society for Bioscience Biotechnology and Agrochemistry, Tokyo, JAPON  (1992) (Revue)

Mots-clés anglais / English Keywords

Food

;

Pharmacognosy

;

Antioxidant

;

Antiulcer agent

;

Prevention

;

Polyphenol

;

Phenols

;

Plant origin

;

Medicinal plant

;

Theobroma cacao

;

Cocoa liquor

;

Ulcer

;

Biological activity

;

Rat

;

Animal

;

Intragastric administration

;

Mechanism of action

;

Sterculiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Gastric disease

;

Digestive diseases

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

Aliment

;

Pharmacognosie

;

Antioxydant

;

Antiulcéreux

;

Prévention

;

Polyphénol

;

Phénols

;

Origine végétale

;

Plante médicinale

;

Theobroma cacao

;

Pâte cacao

;

Ulcère

;

Activité biologique

;

Rat

;

Animal

;

Voie intragastrique

;

Mécanisme action

;

Sterculiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Estomac pathologie

;

Appareil digestif pathologie

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

Alimento

;

Farmacognosia

;

Antioxidante

;

Antiulceroso

;

Prevención

;

Polifenol

;

Fenoles

;

Origen vegetal

;

Planta medicinal

;

Theobroma cacao

;

Pasta cacao

;

Ulcera

;

Actividad biológica

;

Rata

;

Animal

;

Vía intragástrica

;

Mecanismo acción

;

Sterculiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Estómago patología

;

Aparato digestivo patología

;

Rodentia

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 8935, 35400007302632.0120

Nº notice refdoc (ud4) : 1631562



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