Titre du document / Document title

Relationship between the -374T/A RAGE gene polymorphism and angiographic coronary artery disease

Auteur(s) / Author(s)

FALCONE Colomba ; CAMPO Ilaria ; EMANUELE Enzo ; BUZZI Maria P. ; ZORZETTO Michele ; SBARSI Ilaria ; CUCCIA Mariaclara ;

Résumé / Abstract

The receptor for advanced glycation end products (RAGE) is thought to play a critical role in diabetic atherosclerosis. Accordingly, a functional -374T/A polymorphism in RAGE gene promoter has been associated with macrovascular complications in type 1 diabetic patients. However, the extent to which this common variant influences the risk of coronary artery disease (CAD) in the general population remains to be determined. We genotyped the -374T/A RAGE polymorphism in 259 non-diabetic individuals, of whom 175 had angiographically documented coronary artery disease (CAD patients) and 84 had normal coronary angiography (CAD-free control subjects). Homozygosity for the -374A allele was found in 9.7% of the CAD patients versus 22.6% of the CAD-free subjects (p=0.005). By means of a multiple logistic regression analysis, the AA genotype of the -374T/A polymorphism was shown to be independently associated with a reduced risk of CAD (adjusted odds ratio 0.33, 95% CI 0.15 to 0.73; p=0.006). Our observations suggest that the -374T/A polymorphism of the RAGE gene may reduce susceptibility to CAD, thus exerting a protective effect on coronary risk. Future pathophysiological studies may be worthwhile to clarify the mechanisms behind this association.

Revue / Journal Title

International journal of molecular medicine   ISSN 1107-3756 

Source / Source

2004, vol. 14, n^o6, pp. 1061-1064 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

D.A. Spandidos, Athens, GRECE  (1998) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 27038, 35400012284106.0150