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Titre du document / Document title

Los leucocitos polimorfonucleares disminuyen la capacidad inmunoestimuladora de las celulas dendriticas = Polymorphonuclear leukocytes decrease the immunostimulatory capacity of human dendritic cells

Auteur(s) / Author(s)

MAFFIA Paulo ; ZITTERMANN Sandra ; SCIMONE Maria Lucila ; BUZZOLA Fernanda ; TATEOSIAN Nancy ; LUTZKY Viviana ; JANCIC Carolina ; BARBOSA Marcos ; CHULUYAN Eduardo ;

Résumé / Abstract

The aim of this work was to evaluate the ability of polymorphonuclear leukocytes (PMNL) to modulate the function of dendritic cells (DCs). Human DCs were used to analyze the effect of PMNL on DCs. The allostimulatory proliferation of T cells induced by DCs incubated with PMNL was lower (42 ′ 14%, n:8, p< 0.05) compared with untreated DCs. The decreased proliferation correlated with lower IFNy production (DCs: 781′3 pg/ ml; DCs-CS: 343′178 pg/ml, p<0.05). The same effect was observed in an antigen specific assay. However, the effect was not observed when PMNL where incubated with mature DCs. Indeed, the effect of PMNL was partially reverted with serine proteases inhibitors. Overall, these results suggest that PMNL modulates DCs activity by serine proteases.

Revue / Journal Title

Medicina    ISSN  0025-7680   CODEN MEDCAD 

Source / Source

2004, vol. 64, no5, pp. 433-435 [3 page(s) (article)]

Langue / Language


Editeur / Publisher

Fundación Revista Medicina, Buenos Aires, ARGENTINE  (1940) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 10720, 35400012274008.0090

Nº notice refdoc (ud4) : 16279357

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