Titre du document / Document title

Latent autoimmune diabetes mellitus in children (LADC) with autoimmune thyroiditis and celiac disease

Auteur(s) / Author(s)

AYCAN Zehra ; BERBEROGLU Merih ; ADIYAMAN Pelin ; ERGüR Ayca Torel ; ENSARI Arzu ; EVLIYAOGLU Olcay ; SIKLAR Zeynep ; OCAL Gönül ;

Résumé / Abstract

Latent autoimmune diabetes mellitus in adults (LADA) is characterized by clinical presentation as type 2 diabetes mellitus after 25 years of age, initial control achieved with oral hypoglycemic agents for at least 6 months, presence of autoantibodies and some immuno-genetic features of type 1 diabetes mellitus. An 8.3 year-old girl was referred to our pediatric endocrinology department because of incidental glucosuria. She did not complain of polyuria, polydipsia, or weight loss. Her body mass index (BMI) was at the 80_th percentile. Fasting glucose was 126 mg/dl, and OGTT glucose level at 120 min was 307 mg/dl. Although C-peptide levels were normal, her first phase insulin response (FIR) was lower than the 1_st percentile. Anti-insulin antibody (AIA), islet cell antibody (ICA), and anti-glutamic acid decarboxylase (antiGAD) were negative. According to the clinical and laboratory findings, she was diagnosed as having type 2 diabetes mellitus. She was started with oral anti-diabetic treatment for a period of 1 year. Insulin had to be initiated for worsening of HbA^1c levels. In the fourth year of follow-up, she was admitted to our hospital with diabetic ketoacidosis although she was on an intensive insulin regimen. At this time, C-peptide levels were low, antiGAD and AIA were positive with HLA DR3/DQ2 haplotype. In addition, her thyroid peroxidase antibody and endomysium antibody were found to be high at follow-up. Small intestinal biopsy revealed celiac disease. This patient may represent the first case of latent autoimmune diabetes mellitus in children (LADC) with autoimmune thyroiditis and celiac disease.

Revue / Journal Title

Journal of pediatric endocrinology & metabolism   ISSN 0334-018X 

Source / Source

2004, vol. 17, n^o11, pp. 1565-1569 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Freund, Tel Aviv, ISRAEL  (1985) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 20997, 35400012252434.0140