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Titre du document / Document title

Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies

Auteur(s) / Author(s)

EDWARDS Mark J. (1) ; DALE Russell C. (2 3) ; CHURCH Andrew J. (2) ; TRIKOULI Eleni (1) ; QUINN Niall P. (1) ; LEES Andrew J. (4) ; GIOVANNONI Gavin (2) ; BHATIA Kailash P. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, ROYAUME-UNI
(2) Neuroimmunology unit, Department of Neuroinflammation. Institute of Neurology, University College London, Queen Square, London, ROYAUME-UNI
(3) Neurosciences unit, Institute of Child Health., London, ROYAUME-UNI
(4) The Reta Lila Weston Institute of Neurological Studies, The Windeyer Building, London, ROYAUME-UNI

Résumé / Abstract

The onset of tics in adulthood is rare and, unlike the childhood variety, there is commonly a secondary environmental cause. We present four cases (1 man, 3 women) with an adult onset tic disorder (mean age of onset, 36 years; range, 27-42 years) associated with the presence of serum antibasal ganglia antibodies (ABGA). One patient had motor tics and unusual motor stereotypies, 2 had multiple motor and vocal tics, and the remaining patient had motor tics only. Concomitant psychiatric disturbance was noted in 3 cases. In 2 cases, there was a close temporal relationship between upper respiratory tract infection and the subsequent onset of tics. Imaging was possible in three cases and was normal in two but revealed a lesion involving the right caudate and lentiform nuclei in the other. We suggest that there might be a causal relationship between ABGA and the clinical syndrome in these cases and that ABGA should be considered as a possible etiology for adult-onset tics.

Revue / Journal Title

Movement disorders    ISSN  0885-3185 

Source / Source

2004, vol. 19, no10, pp. 1190-1196 [7 page(s) (article)] (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1986) (Revue)

Mots-clés anglais / English Keywords

Neurological disorder

;

Involuntary movement

;

Motor control

;

Motor system disorder

;

Tic

;

Stereotypy

;

Nervous system diseases

;

Mots-clés français / French Keywords

Trouble neurologique

;

Mouvement involontaire

;

Contrôle moteur

;

Trouble moteur

;

Tic

;

Stéréotypie

;

Système nerveux pathologie

;

Mots-clés espagnols / Spanish Keywords

Trastorno neurológico

;

Movimiento involuntario

;

Control motor

;

Trastorno motor

;

Tic

;

Estereotipia

;

Sistema nervioso patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 20953, 35400012247434.0090

Nº notice refdoc (ud4) : 16202816



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