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Titre du document / Document title

Fish oil supplementation in the treatment of cachexia in pancreatic cancer patients

Auteur(s) / Author(s)

BROWN Todd T. (1) ; ZELNIK Danielle L. (1) ; DOBS Adrian S. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Center for Complementary and Alternative Medicine, Baltimore, MD, ETATS-UNIS

Résumé / Abstract

Patients with pancreatic cancer often experience a loss of weight and appetite, known as the anorexia-cachexia syndrome, which is associated with decreased quality of life and reduced survival. Research into the biological mechanisms of cachexia has demonstrated that an array of inflammatory mediators and tumor-derived factors cause appetite suppression, skeletal muscle proteolysis, and lipolysis, producing an overall hypercatabolic state that contributes to loss of fat and lean body mass. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been shown to modulate levels of proinflammatory cytokines, hepatic acute phase proteins, eicosanoids, and tumor-derived factors in animal models of cancer and may reverse some aspects of the process of cachexia. Results of clinical trials of n-3 PUFAs in the form of fish oils have been mixed, but should encourage further investigation into dietary fish oil supplementation, including the most effective route of administration and the proper dosage to promote optimal weight maintenance and to limit side effects. Concerns about standardization and quality control should also be considered. With the current available evidence, a recommendation for the use of omega 3 polyunsaturated fatty acids in pancreatic cancer cachexia is premature.

Revue / Journal Title

International journal of gastrointestinal cancer    ISSN  1537-3649 

Source / Source

2003, vol. 34, no2-3, pp. 143-150 [8 page(s) (article)] (50 ref.)

Langue / Language

Anglais

Editeur / Publisher

Humana Press, Totowa, NJ, ETATS-UNIS  (2001-2006) (Revue)

Mots-clés anglais / English Keywords

Pancreatic disease

;

Digestive diseases

;

Pancreas cancer

;

Gastroenterology

;

Polyunsaturated fatty acid

;

Fatty acids

;

Anorexia

;

Malignant tumor

;

Human

;

Cachexia

;

Treatment

;

Supplementation

;

Fish oil

;

Mots-clés français / French Keywords

Pancréas pathologie

;

Appareil digestif pathologie

;

Cancer du pancréas

;

Gastroentérologie

;

Acide gras polyinsaturé

;

Acide gras

;

Anorexie

;

Tumeur maligne

;

Homme

;

Cachexie

;

Traitement

;

Supplémentation

;

Huile poisson

;

Mots-clés espagnols / Spanish Keywords

Páncreas patología

;

Aparato digestivo patología

;

Cáncer del páncreas

;

Gastroenterología

;

Acido graso poliinsaturado

;

Acido graso

;

Anorexia

;

Tumor maligno

;

Hombre

;

Caquexia

;

Tratamiento

;

Suplementación

;

Aceite pescado

;

Mots-clés d'auteur / Author Keywords

Cancer

;

pancreatic cancer

;

cachexia

;

anorexia

;

fish oil

;

omega-3 fatty acids

;

polyunsaturated fatty acids

;

Localisation / Location

INIST-CNRS, Cote INIST : 21155, 35400012064524.0140

Nº notice refdoc (ud4) : 16197625



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