Titre du document / Document title

Elevated soluble cell adhesion molecules E-selectin and intercellular cell adhesion molecule-1 in type-2 diabetic patients with and without asymptomatic peripheral arterial disease

Auteur(s) / Author(s)

ELHADD T. A. ⁽¹⁾ ; KENNEDY G. ⁽¹⁾ ; ROBB R. ⁽¹⁾ ; MCLAREN M. ⁽¹⁾ ; JUNG R. T. ⁽²⁾ ; BELCH J. J. F. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Section of Vasciular Biology and Medicine, University and Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, ROYAUME-UNI
⁽²⁾ Diabetes Centre, Ninewells Hospital and Medical School, Dundee, Scotland, ROYAUME-UNI

Résumé / Abstract

Aim. Cell adhesion molecules may serve as markers of endothelial cell activation, and they may well have a role in the pathogenesis of atherosclerotic vascular disease in diabetes mellitus. Methods. Experimental design: a cross sectional, comparative study. Setting: a teaching University Hospital. Patients and controls. A cohort of diabetic patients with absent peripheral arterial pulses but no history of cardiovascular or cerebrovascular disease i.e. asymptomatic (n=29), median age 68 (36-80) years, (range), diabetes duration 10 (1-43) years and HbAlc 7.7% (4.8-9.6). They were compared to 12 age and sex matched normal non-diabetic controls. Intervention: none. Measures: soluble cell adhesion molecules intercellular cell adhesion molecule-1 (ICAM-1) and E-selectin levels measured by ELISA methods. Results. The 29 patients with diabetes, as a whole, were found to have significantly higher median plasma sICAM-1 and sE-selectin of 283 nglml (154-1 000) (range), and 65.8 ng/ml (20.6-145) vs 237 (147-312.4) and 37.7 (19.8-46.6) respectively, Mann Whitney U test p<0.02, and p<0.002. In the diabetic group, E-selectin correlated with ICAM-1, age and HbAlc: r=0.524 p<0.01, r=0.385 p<0.05 and r=0.393 p<0.05 respectively (Spearman correlation coefficient). Conclusion. These results confirm that elevated levels of adhesion molecules, E-selectin and ICAM-1 occur in Type-2 diabetes early in the course of asymptomatic peripheral arterial occlusive disease, and this is related to glycemic control. This suggests that adhesion molecules may have a role in the pathogenesis of atherosclerotic vascular disease in diabetes.

Revue / Journal Title

International angiology   ISSN 0392-9590 

Source / Source

2004, vol. 23, n^o2, pp. 128-133 [6 page(s) (article)] (34 ref.)

Langue / Language

Anglais

Editeur / Publisher

Minerva Medica, Torino, ITALIE  (1982) (Revue)

Mots-clés anglais / English Keywords

Vascular disease ; Endocrinopathy ; Arterial disease ; Endothelium ; Asymptomatic ; Arteriopathy ; Human ; Intercellular adhesion molecule 1 ; Type 2 diabetes ; E Selectin ; Cell adhesion molecule ; Cardiovascular disease ;

Mots-clés français / French Keywords

Vaisseau sanguin pathologie ; Endocrinopathie ; Artère pathologie ; Endothélium ; Asymptomatique ; Artériopathie ; Homme ; Protéine ICAM1 ; Diabète type 2 ; Sélectine E ; Protéine CAM ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Vaso sanguíneo patología ; Endocrinopatía ; Arteria patología ; Endotelio ; Asintomático ; Arteriopatía ; Hombre ; Proteína ICAM1 ; Diabetes de tipo 2 ; Selectin E ; Proteína CAM ; Aparato circulatorio patología ;

Mots-clés d'auteur / Author Keywords

Diabetes mellitus ; Cell adhesion molecules ; Endothelium vascular, physiology ; E-selectin ; Intercellular adhesion molecule 1 ;

Localisation / Location

INIST-CNRS, Cote INIST : 19982, 35400012048733.0060