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Titre du document / Document title

Cingulate gyrus volume and metabolism in the schizophrenia spectrum

Auteur(s) / Author(s)

MEHMET HAZNEDAR M. (1) ; BUCHSBAUM Monte S. (1) ; HAZLETT Erin A. (1) ; SHIHABUDDIN Lina (1 2) ; NEW Antonia (1 2) ; SIEVER Larry J. (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L. Levy Place, P.O. Box 1505, New York, NY 10029-6574, ETATS-UNIS
(2) Department of Psychiatry, 116A, Bronx VA Medical Center, 130 W Kingsbridge Rd., Bronx, NY 10468, ETATS-UNIS

Résumé / Abstract

Background: The cingulate gyrus, which is involved in affect, attention, memory and higher executive functions, has been implicated as a dysfunctional region in schizophrenia. Postmortem studies report cytoarchitectural changes in the anterior cingulate gyrus (ACG) and functioning imaging studies show correlations between the degree of hypometabolism of the anterior cingulate and clinical symptoms in schizophrenia. Methods: Unmedicated patients with schizophrenia (n=27) and schizotypal personality disorder (SPD) (n= 13), as well as sex- and age-matched control subjects (n=32), were studied with 18F-fluorodeoxyglucose positron emission tomography (PET) scans and magnetic resonance imaging (MRI). As a control over mental activity, all subjects performed a verbal working memory task during the PET protocol. The cingulate gyrus was first outlined on the MRI scans and, after coregistration, the coordinates were applied to the PET scans to yield a three-dimensional metabolic map of the cingulate gyrus for each subject. A statistical resampling method was used to analyze the metabolic differences between groups. Results: Compared with controls, patients with schizophrenia had lower relative glucose metabolic rates in the left anterior cingulate and the right posterior cingulate gyrus (PCG) assessed by 3-D significance probability mapping. SPD patients had higher glucose metabolic rates (GMRs) in the left posterior cingulate than did controls. Furthermore, volumetric measurement with MRI showed the left anterior cingulate and Brodmann area 24' to be smaller in schizophrenic patients than controls. Conclusions: Compared with controls, patients with schizophrenia have metabolic and volumetric reductions in a cingulate gyrus area that is related to higher executive functions. Schizotypal patients rely more on sensory association areas to perform a cognitive task than do controls and seem to be a group that is partially distinct in its physiological and functional characteristics.

Revue / Journal Title

Schizophrenia research    ISSN  0920-9964 

Source / Source

2004, vol. 71, no2-3, pp. 249-262 [14 page(s) (article)] (2 p.3/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1988) (Revue)

Mots-clés anglais / English Keywords

Radionuclide study

;

Medical imagery

;

Personality disorder

;

Central nervous system

;

Encephalon

;

Human

;

Cognition

;

Emission tomography

;

Nuclear magnetic resonance imaging

;

Glucose

;

Metabolism

;

Schizotypal personality

;

Volumetric analysis

;

Morphometry

;

Cingulate cortex

;

Schizophrenia

;

Mots-clés français / French Keywords

Exploration radioisotopique

;

Imagerie médicale

;

Trouble personnalité

;

Système nerveux central

;

Encéphale

;

Homme

;

Cognition

;

Tomoscintigraphie

;

Imagerie RMN

;

Glucose

;

Métabolisme

;

Personnalité schizotypique

;

Volumétrie

;

Morphométrie

;

Cortex cingulaire

;

Schizophrénie

;

Mots-clés espagnols / Spanish Keywords

Exploración radioisotópica

;

Imaginería médica

;

Trastorno personalidad

;

Sistema nervioso central

;

Encéfalo

;

Hombre

;

Cognición

;

Tomocentelleografía

;

Imaginería RMN

;

Glucosa

;

Metabolismo

;

Personalidad esquizotípica

;

Volumetría

;

Morfometría

;

Corteza cingular

;

Esquizofrenia

;

Mots-clés d'auteur / Author Keywords

Cingulate gyrus

;

Schizophrenia

;

Schizotypal personality disorder

;

Localisation / Location

INIST-CNRS, Cote INIST : 21734, 35400012237187.0050

Nº notice refdoc (ud4) : 16185793



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