Titre du document / Document title

The androgenic profile of women with non-insulin-dependent diabetes mellitus

Auteur(s) / Author(s)

TOK Ekrem C. ; ERTUNC Devrim ; EVRUKE Cuneyt ; DILEK Saffet ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Departments of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, TURQUIE
Mustafa Kemal University School of Medicine, Hatay, TURQUIE
Cukurova University School of Medicine, Adana, TURQUIE
Zekai Tahir Burak Maternity Hospital, Ankara, TURQUIE

Résumé / Abstract

OBJECTIVE: To evaluate the androgenic profile of women with non-insulin-dependent diabetes mellitus. STUDY DESIGN: This case-control study evaluated the clinical, hormonal and ultrasonographic characteristics of women of reproductive age with non-insulin-dependent diabetes mellitus and compared them with those of age- and weight-matched controls. Radioimmunoassays were used for total testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS) and androstenedione. Sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were analyzed by fluoroininiufioassays. Ovarian appearance and volume were assessed by transvaginal or transabdominal ultrasonography. RESULTS: The prevalence of polycystic ovary syndrome was higher in diabetic patients than in the general population as reported earlier. Hirsutism was also more prevalent in diabetic patients (p < 0.05). The serum levels of FSH, LH, estradiol, total testosterone, androstenedione and DHEAS were significantly higher in diabetic patients than in the control group (p <0.05). In contrast, the levels of SHBG were lower in diabetic patients (p<0.05). The rates of ultrasonographically apparent polycystic ovaries and greater ovarian volumes were also higher in diabetic patients (p < 0.05). CONCLUSION: Women with non-insulin-dependent diabetes mellitus seem to have biochemical and clinical hyperandrogenism when compared with nondiabetic controls.

Revue / Journal Title

Journal of reproductive medicine   ISSN 0024-7758   CODEN JRPMAP 

Source / Source

2004, vol. 49, n^o9, pp. 746-752 [7 page(s) (article)] (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

Science, Saint-Louis, MO, ETATS-UNIS  (1969) (Revue)

Mots-clés anglais / English Keywords

Female sterility ; Cyst ; Benign neoplasm ; Ovarian diseases ; Female genital diseases ; Sex steroid hormone ; Pancreatic hormone ; Endocrinopathy ; Polycystic ovary ; Androgen ; Obstetrics ; Gynecology ; Insulin ; Female ; Human ; Type 2 diabetes ;

Mots-clés français / French Keywords

Stérilité femelle ; Kyste ; Tumeur bénigne ; Ovaire pathologie ; Appareil génital femelle pathologie ; Hormone stéroïde sexuelle ; Hormone pancréatique ; Endocrinopathie ; Ovaire polykystique ; Androgène ; Obstétrique ; Gynécologie ; Insuline ; Femelle ; Homme ; Diabète type 2 ;

Mots-clés espagnols / Spanish Keywords

Esterilidad femenina ; Quiste ; Tumor benigno ; Ovario patología ; Aparato genital hembra patología ; Hormona esteroide sexual ; Hormona pancreática ; Endocrinopatía ; Ovario poliquístico ; Andrógeno ; Obstétrico ; Ginecología ; Insulina ; Hembra ; Hombre ; Diabetes de tipo 2 ;

Mots-clés d'auteur / Author Keywords

diabetes ; non-insulin-dependent;androgens; polycystic ovary syndrome ;

Localisation / Location

INIST-CNRS, Cote INIST : 17097, 35400012226974.0090