Titre du document / Document title

Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa

Auteur(s) / Author(s)

RADTKE Norman D. ⁽¹⁾ ; ARAMANT Robert B. ^{(1 2)} ; SEILER Magdalene J. ⁽³⁾ ; PETRY Heywood M. ⁽⁴⁾ ; PIDWELL Diane ⁽⁵⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Retina Vitreous Resource Center, Norton Audubon Hospital, ETATS-UNIS
⁽²⁾ Department of Anatomical Sciences and Neurobiology, University of Louisville, Kentucky, ETATS-UNIS
⁽³⁾ Delany Retina Institute, Departments of Ophthalmology and Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, ETATS-UNIS
⁽⁴⁾ Department of Ophthalmology and Visual Sciences and Psychological and Brain Sciences, University of Louisville, Kentucky, ETATS-UNIS
⁽⁵⁾ Tissue Typing Laboratory, Jewish Hospital, Louisville, ETATS-UNIS

Résumé / Abstract

Objective: To report the subjective and objective improvement in vision in a patient with autosomal dominant retinitis pigmentosa after transplantation of a sheet of fetal neural retina together with its retinal pigment epithelium. Design: A sheet of fetal neural retina with its retinal pigment epithelium was transplanted into the subretinal space under the fovea unilaterally in a patient with retinitis pigmentosa with visual acuity of 20/800 in the treated eye. Early Treatment Diabetic Retinopathy Study visual acuity testing, scanning laser ophthalmoscope, tissue typing of the donor and recipient, fluorescein angiography, multifocal electroretinogram, multifocal visually evoked potential, and clinical examination were used. Results: No clinical evidence of rejection was observed. There was no retinal edema or scarring. The transplant sheet lost its pigmentation by 6 months. Main Outcome Measures: A change in visual acuity from 20/800 to 20/400 (7 months), 20/250 (9 months), and 20/160 (1 year) was observed by Early Treatment Diabetic Retinopathy Study visual acuity testing. Independently, scanning laser ophthalmoscope testing at a different institution at 9 months showed a visual acuity of 20/270 at a 40° field of view. Conclusion: This study indicates that fetal retina transplanted with its retinal pigment epithelium can survive 1 year without apparent clinical evidence of rejection and show continued improvement in Early Treatment Diabetic Retinopathy Study visual acuity.

Revue / Journal Title

Archives of ophthalmology   ISSN 0003-9950 

Source / Source

2004, vol. 122, n^o8, pp. 1159-1165 [7 page(s) (article)] (38 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Medical Association, Chicago, IL, ETATS-UNIS  (1960) (Revue)

Mots-clés anglais / English Keywords

Retinopathy ; Eye disease ; Genetic disease ; Ophthalmology ; Patient ; Human ; Pigment epithelium ; Retinal ; Retina ; Change ; Vision ; Retinitis pigmentosa ;

Mots-clés français / French Keywords

Rétinopathie ; Oeil pathologie ; Maladie héréditaire ; Ophtalmologie ; Malade ; Homme ; Epithélium pigmentaire ; Rétinal ; Rétine ; Changement ; Vision ; Rétinite pigmentaire ;

Mots-clés espagnols / Spanish Keywords

Retinopatía ; Ojo patología ; Enfermedad hereditaria ; Oftalmología ; Enfermo ; Hombre ; Epitelio pigmentario ; Retinal ; Retina ; Cambio ; Visión ; Retinitis pigmentaria ;

Localisation / Location

INIST-CNRS, Cote INIST : 2033, 35400011395465.0080