Titre du document / Document title
Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage
Auteur(s) / Author(s)
TEMEL Yasin (1 2) ;
VISSER-VANDEWALLE Veerle (2) ;
VAN DER WOLF Martin (3) ;
SPINCEMAILLE Geert H. (2) ;
DESBONNET Lieve (1 4) ;
HOOGLAND Govert (2) ;
STEINBUSCH Harry W. M. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Neuroscience, European Graduate School of Neurooscience (EURON), Maastricht University, Maastricht, PAYS-BAS
(2) Department of Neurosurgery, University Hospital Maastricht, P. Debyelaan 25, 6202 AZ Maastricht, PAYS-BAS
(3) Instrument Development Engineering and Evaluation (IDEE), Maastricht University, Maastricht, PAYS-BAS
(4) Department of Pharmacology, National University of Ireland, Galway, IRLANDE
Résumé / Abstract
The aim of the present study was to determine the effects of monopolar and bipolar high frequency stimulation (HFS) on histological damage and current flow using a commonly applied stimulus amplitude (300 μA). Bipolar HFS resulted in a large amount of histological damage whereas with monopolar HFS no damage was observed except for the electrode trajectory. Oscilloscopic readings confirmed that this was due to the application of twice as much current to the target with bipolar HFS. Our results demonstrate that there are differences in tissue damage dependent of polarity. In order to create a better comparison to the clinical condition, we suggest that the present rodent models for studying the effect of chronic HFS require further adjustment. This can be achieved by decreasing the present current densities to a level comparable to the human situation.
Revue / Journal Title
Neuroscience letters
ISSN
0304-3940
CODEN NELED5
Source / Source
2004, vol. 367, n
o1, pp. 92-96 [5 page(s) (article)] (21 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Shannon, IRLANDE
(1975)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 17240, 35400011620136.0210
Nº notice refdoc (ud4) : 16008820
