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Titre du document / Document title

Monopolar versus bipolar high frequency stimulation in the rat subthalamic nucleus: differences in histological damage

Auteur(s) / Author(s)

TEMEL Yasin (1 2) ; VISSER-VANDEWALLE Veerle (2) ; VAN DER WOLF Martin (3) ; SPINCEMAILLE Geert H. (2) ; DESBONNET Lieve (1 4) ; HOOGLAND Govert (2) ; STEINBUSCH Harry W. M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neuroscience, European Graduate School of Neurooscience (EURON), Maastricht University, Maastricht, PAYS-BAS
(2) Department of Neurosurgery, University Hospital Maastricht, P. Debyelaan 25, 6202 AZ Maastricht, PAYS-BAS
(3) Instrument Development Engineering and Evaluation (IDEE), Maastricht University, Maastricht, PAYS-BAS
(4) Department of Pharmacology, National University of Ireland, Galway, IRLANDE

Résumé / Abstract

The aim of the present study was to determine the effects of monopolar and bipolar high frequency stimulation (HFS) on histological damage and current flow using a commonly applied stimulus amplitude (300 μA). Bipolar HFS resulted in a large amount of histological damage whereas with monopolar HFS no damage was observed except for the electrode trajectory. Oscilloscopic readings confirmed that this was due to the application of twice as much current to the target with bipolar HFS. Our results demonstrate that there are differences in tissue damage dependent of polarity. In order to create a better comparison to the clinical condition, we suggest that the present rodent models for studying the effect of chronic HFS require further adjustment. This can be achieved by decreasing the present current densities to a level comparable to the human situation.

Revue / Journal Title

Neuroscience letters    ISSN  0304-3940   CODEN NELED5 

Source / Source

2004, vol. 367, no1, pp. 92-96 [5 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1975) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Central nervous system

;

Animal

;

Rat

;

Encephalon

;

Subthalamic nucleus

;

High frequency

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Système nerveux central

;

Animal

;

Rat

;

Encéphale

;

Noyau sousthalamique

;

Haute fréquence

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Sistema nervioso central

;

Animal

;

Rata

;

Encéfalo

;

Núcleo subtalámico

;

Alta frecuencia

;

Mots-clés d'auteur / Author Keywords

Deep brain stimulation

;

High frequency stimulation

;

Monopolar

;

Bipolar: Subthalamic nucleus: Current density

;

Localisation / Location

INIST-CNRS, Cote INIST : 17240, 35400011620136.0210

Nº notice refdoc (ud4) : 16008820



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