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Titre du document / Document title

Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old danish children

Auteur(s) / Author(s)

HOPPE Camilla ; UDAM Tina Rovenna ; LAURITZEN Lotte ; MØLGAARD Christian ; JUUL Anders ; MICHAELSEN Kim Fleischer ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Human Nutrition and the Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, DANEMARK
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, DANEMARK

Résumé / Abstract

Background: Studies from developing countries indicate that intake of animal protein, especially of milk, is associated with greater velocity of linear growth in childhood. Whether the same association exists in industrialized countries, where protein intake is high, is not clear. Objective: Our objective was to examine associations between protein intake, serum insulin-like growth factor I (sIGF-I) concentrations, and height in healthy children. Design: We analyzed the associations between protein intake, sIGF-I concentrations, and height in 2.5-y-old children. Diet (7-d record) and sIGF-I (radioimmunoassay) data were available from 90 children (54 boys). Results: The 10th, 50th, and 90th percentiles of protein intake were 2.4, 2.9, and 4.0 g.kg-1.d-1, respectively; 63% was animal protein. In multiple linear regressions with adjustment for sex and weight, height (cm) was positively associated with intakes of animal protein (g/d) [0.10 ± 0.038 (b ± SE); P = 0.01] and milk (0.0047 ± 0.002; P = 0.007), but not with those of vegetable protein or meat. The sIGF-I concentration was significantly associated with intakes of animal protein (1.4 ± 0.53; P = 0.01) and milk (0.049 ± 0.024; P = 0.045), but not with those of vegetable protein or meat. sIGF-I concentrations were positively associated with height (0.019 ± 0.008; P = 0.02). Conclusion: Milk intake was positively associated with sIGF-I concentrations and height. An increase in milk intake from 200 to 600 mL/d corresponded to a 30% increase in circulating IGF-I. This suggests that milk compounds have a stimulating effect on sIGF-I concentrations and, thereby, on growth.

Revue / Journal Title

The American journal of clinical nutrition    ISSN  0002-9165   CODEN AJCNAC 

Source / Source

2004, vol. 80, no2, pp. 447-452 [6 page(s) (article)] (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Society for Nutrition, Bethesda, MD, ETATS-UNIS  (1954) (Revue)

Mots-clés anglais / English Keywords

Human

;

Child

;

Danish

;

Growth

;

Insulin like growth factor 1

;

Serum protein

;

Animal protein

;

Mots-clés français / French Keywords

Homme

;

Enfant

;

Danois

;

Croissance

;

Facteur croissance IGF1

;

Protéine sérique

;

Protéine animale

;

Mots-clés espagnols / Spanish Keywords

Hombre

;

Niño

;

Danés

;

Crecimiento

;

Factor crecimiento IGF1

;

Proteína sérica

;

Proteína animal

;

Mots-clés d'auteur / Author Keywords

Dietary protein

;

animal protein

;

vegetable protein

;

children

;

insulin-like growth factor I

;

milk

;

meat

;

growth

;

Localisation / Location

INIST-CNRS, Cote INIST : 8263, 35400011379741.0300

Nº notice refdoc (ud4) : 15963966



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