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Titre du document / Document title

The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?

Auteur(s) / Author(s)

WHITEMAN Matthew (1) ; ARMSTRONG Jeffrey S. (1) ; SIEW HWA CHU (1) ; JIA-LING Siau (1) ; WONG Boon-Seng (1) ; NAM SANG CHEUNG (1) ; HALLIWELL Barry (1) ; MOORE Philip K. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Biochemistry,, Faculty of Medicine, National University of Singapore, SINGAPOUR
(2) Departments of Pharmacology, Faculty of Medicine, National University of Singapore, SINGAPOUR

Résumé / Abstract

Hydrogen sulfide (H2S) is a well-known cytotoxic gas. Recently it has been shown to stimulate N-methyl-D-aspartate (NMDA) receptors to enhance long-term potentiation suggesting a novel neuromodulatory role in vivo. Endogenous levels of H2S in the brain are reported to range between 10 and 160 μM. Considerably lower H2S levels are reported in the brains of Alzheimer's disease (AD) patients, where levels of brain protein nitration (probably mediated by peroxynitrite) are markedly increased. Activation of NMDA receptors leads to intracellular tyrosine nitration by peroxynitrite. Because H2S and peroxynitrite are important mediators in brain function and disease, we investigated the effects of the H2S 'donor', sodium hydrogen sulfide (NaSH) on peroxynitrite-mediated damage to biomolecules and to cultured human SH-SY5Y cells. H2S significantly inhibited peroxynitrite-mediated tyrosine nitration and inactivation of α1-antiproteinase to a similar extent to reduced glutathione at each concentration tested (30-250 μM). H2S also inhibited peroxynitrite-induced cytotoxicity, intracellular protein nitration and protein oxidation in human neuroblastoma SH-SY5Y cells. These data suggest that H2S has the potential to act as an inhibitor of peroxynitrite-mediated processes in vivo and that the potential antioxidant action of H2S deserves further study, given that extracellular GSH levels in the brain are very low.

Revue / Journal Title

Journal of neurochemistry    ISSN  0022-3042   CODEN JONRA9 

Source / Source

2004, vol. 90, no3, pp. 765-768 [4 page(s) (article)] (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Oxford, ROYAUME-UNI  (1956) (Revue)

Mots-clés anglais / English Keywords

Hydrogen Sulfides

;

In vitro

;

Cell line

;

Neuroblastoma

;

Gases

;

Cytotoxicity

;

Oxidative stress

;

Degeneration

;

Neuromodulator

;

Mots-clés français / French Keywords

Hydrogène Sulfure

;

In vitro

;

Lignée cellulaire

;

Neuroblastome

;

Gaz

;

Cytotoxicité

;

Stress oxydatif

;

Dégénérescence

;

Neuromodulateur

;

Mots-clés espagnols / Spanish Keywords

Hidrógeno Sulfuro

;

In vitro

;

Línea celular

;

Neuroblastoma

;

Gas

;

Citotoxicidad

;

Estrés oxidativo

;

Degeneración

;

Neuromodulator

;

Mots-clés d'auteur / Author Keywords

3-nitrotyrosine

;

hydrogen sulfide

;

neurodegeneration

;

nitrosative stress

;

oxidative stress

;

peroxynitrite

;

Localisation / Location

INIST-CNRS, Cote INIST : 4037, 35400011401800.0280

Nº notice refdoc (ud4) : 15958547



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