Titre du document / Document title

Novel nitric oxide signaling mechanisms regulate the erectile response

Auteur(s) / Author(s)

BURNETT A. L. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland, ETATS-UNIS

Résumé / Abstract

Nitric oxide (NO) is a physiologic signal essential to penile erection, and disorders that reduce NO synthesis or release in the erectile tissue are commonly associated with erectile dysfunction. NO synthase (NOS) catalyzes production of NO from L-arginine. While both constitutively expressed neuronal NOS (nNOS) and endothelial NOS (eNOS) isoforms mediate penile erection, nNOS is widely perceived to predominate in this role. Demonstration that blood-flow-dependent generation of NO involves phosphorylative activation of penile eNOS challenges conventional understanding of NO-dependent erectile mechanisms. Regulation of erectile function may not be mediated exclusively by neurally derived NO: Blood-flow-induced fluid shear stress in the penile vasculature stimulates phosphatidyl-inositol 3-kinase to phosphorylate protein kinase B, which in turn phosphorylates eNOS to generate NO. Thus, nNOS may initiate cavernosal tissue relaxation, while activated eNOS may facilitate attainment and maintenance of full erection.

Revue / Journal Title

International journal of impotence research   ISSN 0955-9930 

Source / Source

2004, vol. 16, SUP1 (44 p.)  (30 ref.), pp. S15-S19

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1989) (Revue)

Mots-clés anglais / English Keywords

Male genital system ; Oxidoreductases ; Enzyme ; Transferases ; EC 1.14.13.39 ; EC 2.7.1.137 ; Andrology ; Endothelium ; Nitric-oxide synthase ; Erection ; Penis ; 1-Phosphatidylinositol 3-kinase ; Regulation(control) ; Signal transduction ; Nitric oxide ;

Mots-clés français / French Keywords

Appareil génital mâle ; Oxidoreductases ; Enzyme ; Transferases ; EC 1.14.13.39 ; EC 2.7.1.137 ; Andrologie ; Endothélium ; Nitric-oxide synthase ; Erection ; Pénis ; 1-Phosphatidylinositol 3-kinase ; Régulation ; Transduction signal ; Azote monoxyde ;

Mots-clés espagnols / Spanish Keywords

Aparato genital macho ; Oxidoreductases ; Enzima ; Transferases ; Andrología ; Endotelio ; Nitric-oxide synthase ; Erección ; Pene ; 1-Phosphatidylinositol 3-kinase ; Regulación ; Transducción señal ; Nitrógeno monóxido ;

Mots-clés d'auteur / Author Keywords

1-phosphatidylinositol 3-kinase ; penile erection ; nitric-oxide synthase ; endothelium ;

Localisation / Location

INIST-CNRS, Cote INIST : 26573, 35400012012804.0040