Titre du document / Document title
Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis
Auteur(s) / Author(s)
ZEIDNER N. S.
(1) ;
BRANDT K. S.
(1) ;
DADEY E.
(2) ;
DOLAN M. C.
(1) ;
HAPP C.
(1) ;
PIESMAN J.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, ETATS-UNIS
(2) Atrix Laboratories, Fort Collins, Colorado 80525, ETATS-UNIS
Résumé / Abstract
The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.
Revue / Journal Title
Antimicrobial agents and chemotherapy
ISSN 0066-4804
CODEN AACHAX
Source / Source
2004, vol. 48, n
o7, pp. 2697-2699 [3 page(s) (article)] (22 ref.)
Langue / Language
Anglais
Editeur / Publisher
American Society for Microbiology, Washington, DC, ETATS-UNIS
(1961)
(Revue)
Mots-clés anglais / English Keywords
Tetracycline derivatives ;
Delivery system ;
Vertebrata ;
Mammalia ;
Rodentia ;
Bacteriosis ;
Spirochaetosis ;
Borrelia infection ;
Antibiotic ;
Antibacterial agent ;
Models ;
Mouse ;
Animal ;
Bite ;
Prevention ;
Doxycycline ;
Formulation ;
Lyme disease ;
Dosage form ;
Controlled release form ;
Infection ;
Hyclate ;
Mots-clés français / French Keywords
Tétracycline dérivé ;
Système administration ;
Vertebrata ;
Mammalia ;
Rodentia ;
Bactériose ;
Spirochétose ;
Borréliose ;
Antibiotique ;
Antibactérien ;
Modèle ;
Souris ;
Animal ;
Morsure ;
Prévention ;
Doxycycline ;
Formulation ;
Lyme maladie ;
Forme pharmaceutique ;
Forme libération contrôlée ;
Infection ;
Hyclate ;
Mots-clés espagnols / Spanish Keywords
Tetraciclina derivado ;
Sistema administración ;
Vertebrata ;
Mammalia ;
Rodentia ;
Bacteriosis ;
Espiroquetosis ;
Borreliosis ;
Antibiótico ;
Antibacteriano ;
Modelo ;
Ratón ;
Animal ;
Mordedura ;
Prevención ;
Doxiciclina ;
Formulación ;
Artritis inflamatoria epidémica ;
Forma farmacéutica ;
Forma liberación controlada ;
Infección ;
Hiclato ;
Localisation / Location
INIST-CNRS, Cote INIST : 13334, 35400011366920.0500
Nº notice refdoc (ud4) : 15908056
