Titre du document / Document title
Spontaneous ovarian adenocarcinoma in the domestic turkey breeder hen (Meleagris gallopavo): Effects of photoperiod and melatonin
Auteur(s) / Author(s)MOORE Christopher B.
SIOPES Thomas D.
Résumé / Abstract
OBJECTIVES: The effect of photoperiod or melatonin treatments on ovarian adenocarcinoma in turkey breeder hens (Meleagris gallopavo) was investigated to evaluate the usefulness of this animal as a model for studying ovarian cancer. METHODS: In Experiment 1, photoperiod effects were tested by exposing turkeys with ovarian tumors to 8 wks of short days (8:16LD) followed by a 12 wk period of long days (16:8LD). In Experiment 2, exogenous melatonin was administered to turkeys during long day-induced development of ovarian tumors. In both experiments, the stage of tumor growth was scored weekly on a scale of 0 to 4. RESULTS: It was clear that exposure to short days produced complete regression of tumors, with a mean time to score 0 of 4.4 wks. Following re-exposure to a long photoperiod, all of the same birds showed re-growth of the ovarian tumor with a mean time to first palpable detection of 5.4 wks. When melatonin was administered daily during the long photoperiod (Experiment 2), there was a significant delay in the re-growth of tumors. CONCLUSION: It was clear from this study that the growth of solid ovarian tumors in the turkey breeder hen was promoted by long photoperiods and ceased, to the point of remission, on short photoperiods. Thus, ovarian adenocarcinoma in turkeys can be completely manipulated by photoperiod. In addition, treatment with melatonin attenuates tumor growth in the turkey hen. The results suggest that the domestic turkey hen is a useful in vivo model for studying spontaneous ovarian adenocarcinoma.
Revue / Journal TitleNeuro endocrinology letters
Source / Source
2004, vol. 25, no
1-2, pp. 94-101 [8 page(s) (article)]
Langue / Language
Editeur / Publisher
Society of Integrated Sciences, [S.l.], SUEDE
Localisation / Location
INIST-CNRS, Cote INIST : 18210, 35400011210383.0140
Nº notice refdoc (ud4) : 15903157