RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine

Auteur(s) / Author(s)

KURODA Yoshiki (1) ; NACIONALES Dina C. (1) ; AKAOGI Jun (1) ; REEVES Westley H. (1 2) ; SATOH Minoru (1 2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, ARB-R2-156, 1600 SW Archer Road, P.O. Box 100221, Gainesville, FL 32610-0221, ETATS-UNIS
(2) Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0221, ETATS-UNIS

Résumé / Abstract

Adjuvant oils such as Bayol F (Incomplete Freund's adjuvant: IFA) and squalene (MF59) have been used in human and veterinary vaccines despite poor understanding of their mechanisms of action. Several reports suggest an association of vaccination and various autoimmune diseases, however, few were confirmed epidemiologically and the risk of vaccination for autoimmune diseases has been considered minimal. Microbial components, not the adjuvant components, are considered to be of primary importance for adverse effects of vaccines. We have reported that a single intraperitoneal injection of the adjuvant oils pristane, IFA or squalene induces lupus related autoantibodies to nRNP/Sm and -Su in non-autoimmune BALB/c mice. Induction of these autoantibodies appeared to be associnted with the hydrocarbon's ability to induce IL-12, IL-6, and TNF-α, suggesting a relationship with hydrocarbon's adjuvanticity. Whether this is relevant in human vaccination is a difficult issue due to the complex effects of vaccines and the fact that immunotoxicological effects vary depending on species, route, dose, and duration of administration. Nevertheless, the potential of adjuvant hydrocarbon oils to induce autoimmunity has implications in the use of oil adjuvants in human and veterinary vaccines as well as basic research.

Revue / Journal Title

Biomedicine & pharmacotherapy    ISSN  0753-3322   CODEN BIPHEX 

Source / Source

2004, vol. 58, no 5 (71 p.)  [Document : 13 p.] (106 ref.), pp. 325-337 [13 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Paris, FRANCE  (1982) (Revue)

Mots-clés anglais / English Keywords

Vaccine

;

Autoimmunity

;

Mots-clés français / French Keywords

Vaccin

;

Autoimmunité

;

Mots-clés espagnols / Spanish Keywords

Vacuna

;

Autoinmunidad

;

Mots-clés d'auteur / Author Keywords

Adjuvant

;

Autoimmunity

;

Pristane

;

Localisation / Location

INIST-CNRS, Cote INIST : 4790, 35400011464642.0080

Nº notice refdoc (ud4) : 15892345



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas