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Titre du document / Document title

Positive relationship between androgen and the endocrine disruptor, bisphenol a, in normal women and women with ovarian dysfunction

Auteur(s) / Author(s)

TAKEUCHI Toru ; TSUTSUMI Osamu ; IKEZUKI Yumiko ; TAKAI Yasushi ; TAKETANI Yuji ;

Résumé / Abstract

This study was performed to investigate the serum levels of bisphenol A (BPA), an endocrine disruptor, in women with ovarian dysfunction and obesity. Fasting serum samples were obtained from 19 non-obese and 7 obese womenwith normal menstrual cycles: 7 patients with hyperprolactinemia, 21 patients with hypothalamic amenorrhea, and 13 non-obese and 6 obese patients with polycystic ovary syndrome (PCOS). BPA was measured by an enzyme-linked immunosorbent assay. BPA was detected in all human sera. Serum BPA concentrations were significantly higher in both non-obese and obese women with polycystic ovary syndrome (1.05 ′ 0.10 ng/ml, 1.17 ′ 0.16 ng/ml; p<0.05, respectively) and obese normal women (1.04 ′ 0.09 ng/ml, p<0.05) compared with those in non-obese normal women (0.71 ′ 0.09 ng/ ml). There was no difference among women with hyperprolactinemia, women with hypothalamic amenorrhea, and non-obese normal women. There were significant positive correlations between serum BPA and total testosterone (r = 0.391, p<0.001), free testosterone (r = 0.504, p<0.001), androstenedione (r=0.684, p<0.001), and DHEAS (r=0.514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA.

Revue / Journal Title

Endocrine journal    ISSN  0918-8959 

Source / Source

2004, vol. 51, no2, pp. 165-169 [5 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Japan Endocrine Society, Tokyo, JAPON  (1993) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 8191, 35400011207645.0060

Nº notice refdoc (ud4) : 15886970



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