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Titre du document / Document title

Autologous platelets as a source of proteins for healing and tissue regeneration

Auteur(s) / Author(s)

ANITUA Eduardo (1) ; ANDIA Isabel (2) ; ARDANZA Bruno (1) ; NURDEN Paquita (3 4) ; NURDEN Alan T. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Biotechnology Institute, Osakidetza, Vitoria, ESPAGNE
(2) Basque Health Service, Osakidetza, Vitoria, ESPAGNE
(3) Laboratoire d'Hematologie, Hôpital Cardiologique, Pessac, FRANCE
(4) IFR No 4, Hôpital Cardiologique, Pessac, FRANCE

Résumé / Abstract

Platelets are known for their role in haemostasis where they help prevent blood loss at sites of vascular injury. To do this, they adhere, aggregate and form a procoagulant surface leading to thrombin generation and fibrin formation. Platelets also release substances that promote tissue repair and influence the reactivity of vascular and other blood cells in angiogenesis and inflammation. They contain storage pools of growth factors including PDGF,TGF-β andVEGF as well as cytokines including proteins such as PF4 and CD40L. Chemokines and newly synthesised active metabolites are also released. The fact that platelets secrete growth factors and active metabolites means that their applied use can have a positive influence in clinical situations requiring rapid healing and tissue regeneration.Their administration in fibrin clot or fibrin glue provides an adhesive support that can confine secretion to a chosen site. Additionally, the presentation of growth factors attached to platelets and/or fibrin may result in enhanced activity over recombinant proteins. Dental implant surgery with guided bone regeneration is one situation where an autologous platelet-rich clot clearly accelerates ossification after tooth extraction and/or around titanium implants. The end result is both marked reductions in the time required for implant stabilisation and an improved success rate. Orthopaedic surgery, muscle and/or tendon repair, reversal of skin ulcers, hole repair in eye surgery and cosmetic surgery are other situations where autologous platelets accelerate healing. Our aim is to review these advances and discuss the ways in which platelets may provide such unexpected beneficial therapeutic effects.

Revue / Journal Title

Thrombosis and haemostasis    ISSN  0340-6245   CODEN THHADQ 

Source / Source

2004, vol. 91, no1, pp. 4-15 [12 page(s) (article)] (117 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Treatment

;

Repair

;

Implant

;

Tooth

;

Growth factor

;

Surgery

;

Regeneration

;

Cicatrization

;

Protein

;

Platelet

;

Cytokine

;

Mots-clés français / French Keywords

Traitement

;

Réparation

;

Implant

;

Dent

;

Facteur croissance

;

Chirurgie

;

Régénération

;

Cicatrisation

;

Protéine

;

Thrombocyte

;

Cytokine

;

Mots-clés espagnols / Spanish Keywords

Tratamiento

;

Reparación

;

Implante

;

Diente

;

Factor crecimiento

;

Cirugía

;

Regeneración

;

Cicatrización

;

Proteína

;

Trombocito

;

Citoquina

;

Mots-clés d'auteur / Author Keywords

Platelets

;

growth factors

;

cytokines

;

healing

;

dental implant surgery

;

tissue repair

;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400011042356.0020

Nº notice refdoc (ud4) : 15801576



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