Titre du document / Document title

Plasminogen activator inhibitor-type I: its plasma determinants and relation with cardiovascular risk

Auteur(s) / Author(s)

HOEKSTRA Tiny ⁽¹⁾ ; GELEIJNSE Johanna M. ⁽¹⁾ ; SCHOUTEN Evert G. ⁽¹⁾ ; KLUFT Cees ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Human Nutrition, Wageningen University, Wageningen, PAYS-BAS
⁽²⁾ Gaubius Laboratory, TNO Prevention and Health, Leiden, PAYS-BAS

Résumé / Abstract

The habitual level of PAI-I is influenced by many factors, of which obesity and insulin resistance are the most important. It is possible to reduce plasma PAI-I by changes in life style, e.g. weight reduction and physical activity. Data on potential interactions between environmental and metabolic variables on one hand, and the 4G/5G-polymorphism on the other hand, are still scarce. It becomes more and more clear that PAI-I may possibly not be a major (causal) factor in cardiovascular disease, but its role in inflammation deserves further attention. In the presence of the 4G-allele not only the PAI-I response was more pronounced, but also the response of other acute-phase reactants, which implies that the increases of these reactants are secondary to the increase in PAI-I.A myocardial infarction also provokes an acute phase response. It can thus be hypothesized that the 4G-allele might exacerbate tissue injury during the acute phase after a myocardial infarction, and thereby negatively affect the prognosis.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

2004, vol. 91, n^o5, pp. 861-872 [12 page(s) (article)] (173 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Review ; Bibliographic review ; Blood plasma ; Plasminogen activator inhibitor 1 ; Cardiovascular disease ;

Mots-clés français / French Keywords

Article synthèse ; Revue bibliographique ; Plasma sanguin ; Inhibiteur plasminogen activator 1 ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Artículo síntesis ; Revista bibliográfica ; Plasma sanguíneo ; Inhibidor plasminogen activator 1 ; Aparato circulatorio patología ;

Mots-clés d'auteur / Author Keywords

PAI-I ; determinants ; review ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400011031474.0030