Titre du document / Document title

Transurethral needle ablation versus transurethral resection of the prostate for the treatment of symptomatic benign prostatic hyperplasia: 5-year results of A prospective, randomized, multicenter clinical trial

Auteur(s) / Author(s)

HILL Brian ; BELVILLE William ; BRUSKEWITZ Reginald ; ISSA Muta ; PEREZ-MARRERO Ramon ; ROEHRBORN Claus ; TERRIS Martha ; NASLUND Michael ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland, ETATS-UNIS
Department of Urology, University of Michigan School of Medicine, Ann Arbor, Michigan, ETATS-UNIS
Center for Health Sciences, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, ETATS-UNIS
Department of Urology, Emory University School of Medicine, Atlanta, Georgia, ETATS-UNIS
Urology Health Center, New Port Richey, Florida, ETATS-UNIS
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, ETATS-UNIS
Department of Urology Stanford and Palo Alto Veterans Affairs Medical Center, Palo Alto, California, ETATS-UNIS

Résumé / Abstract

Purpose: We report the 5-year efficacy and safety of transurethral needle ablation of the prostate (TUNA) compared to transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Materials and Methods: A total of 121 men 50 years or older with LUTS secondary to BPH a minimum of 3 months in duration were enrolled in this prospective, randomized clinical trial at 7 medical centers across the United States. Of the participants 65 (54%) were randomly selected to receive TUNA and 56 (46%) were selected to receive TURP. International Prostate Symptom Score, quality of life, peak urinary flow rate, post-void residual urinary volume, and prostate size and configuration were evaluated before the procedure and then annually for 5 years after the procedure. Adverse events were also recorded throughout the study. Results: Improvement from baseline for TUNA and TURP retained statistical significance at each interval for International Prostate Symptom Score, quality of life and peak flow rate. Post-void residual volume was statistically significant at all time points for TURP and at year 5 for TUNA. The TURP group reported 41% retrograde ejaculation, while the TUNA group reported none. The incident of erectile dysfunction, incontinence and stricture formation was also greater in TURP than in TUNA cases with significantly fewer adverse events for TUNA than for TURP. Conclusions: The results of this study demonstrate stable treatment outcomes after 5 years of followup and suggest that TUNA is an attractive treatment option for men with LUTS due to BPH.

Revue / Journal Title

The Journal of urology   ISSN 0022-5347   CODEN JOURAA 

Source / Source

2004, vol. 171 (1), n^o6, pp. 2336-2340 [5 page(s) (article)] (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1917) (Revue)

Mots-clés anglais / English Keywords

Benign neoplasm ; Surgery ; Nephrology ; Urology ; Urinary tract ; Hyperplasia ; Clinical trial ; Prospective ; Result ; Adenoma ; Treatment ; Prostate ; Surgical resection ; Comparative study ; Ablation ; Needle ;

Mots-clés français / French Keywords

Tumeur bénigne ; Chirurgie ; Néphrologie ; Urologie ; Voie urinaire ; Hyperplasie ; Essai clinique ; Prospective ; Résultat ; Adénome ; Traitement ; Prostate ; Résection chirurgicale ; Etude comparative ; Ablation ; Aiguille ;

Mots-clés espagnols / Spanish Keywords

Tumor benigno ; Cirugía ; Nefrología ; Urología ; Vía urinaria ; Hiperplasia ; Ensayo clínico ; Prospectiva ; Resultado ; Adenoma ; Tratamiento ; Prostata ; Resección quirúrgica ; Estudio comparativo ; Ablación ; Aguja ;

Mots-clés d'auteur / Author Keywords

prostate ; prostatic hyperplasia ; transurethral resection of prostate ; urinary tract ;

Localisation / Location

INIST-CNRS, Cote INIST : 2081, 35400011454809.0480