Titre du document / Document title

Natural history of twin disruption sequence

Auteur(s) / Author(s)

ZANKL Andreas ⁽¹⁾ ; BROOKS Daniela ⁽¹⁾ ; BOLTSHAUSER Eugen ⁽²⁾ ; LARGO Remo ⁽³⁾ ; SCHINZEL Albert ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Medical Genetics, University of Zurich, Zurich, SUISSE
⁽²⁾ Department of Neurology, University Children's Hospital, Zurich, SUISSE
⁽³⁾ Department of Growth and Development, University Children's Hospital, Zurich, SUISSE

Résumé / Abstract

Intrauterine death of one fetus in a monochorionic twin pregnancy is associated with high morbidity and mortality in the surviving cotwin. Thromoboplastic material from the dead twin may pass to the circulation of the living twin via placental anastomoses and cause tissue necrosis by direct embolization or by activating intravascular coagulation. Alternatively, acute blood loss into the dying twin through placental anastomoses may result in hypotension and hypoxic-ischemic damage to cerebral and visceral tissue in the surviving twin. The resulting clinical picture is referred to as twin disruption sequence. Affected twins have rarely been followed beyond the neonatal period and the long-term development of such children is unknown. Here, we present a natural history and neurological assessment of 18 patients with twin disruption sequence, whom we have followed over several months to vears.

Revue / Journal Title

American journal of medical genetics   ISSN 0148-7299   CODEN AJMGDA 

Source / Source

2004, vol. 127A, n^o2, pp. 133-138 [6 page(s) (article)] (15 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Liss, New York, NY, ETATS-UNIS  (1977-2002) (Revue)

Mots-clés anglais / English Keywords

Nervous system diseases ; Central nervous system disease ; Cerebral disorder ; Congenital ; Disruption ; Twin ; Cerebral palsy ;

Mots-clés français / French Keywords

Système nerveux pathologie ; Système nerveux central pathologie ; Encéphale pathologie ; Congénital ; Disruption ; Jumeau ; Infirmité motrice cérébrale ;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso patología ; Sistema nervosio central patología ; Encéfalo patología ; Congénito ; Disrupción ; Gemelo ; Encefalopatía infantil ;

Mots-clés d'auteur / Author Keywords

cerebral palsy ; congenital malfomation ; monozygous twins ; monochorionic twins ;

Localisation / Location

INIST-CNRS, Cote INIST : 17405, 35400011191344.0040