Titre du document / Document title

Interethnic variability in birth weight and genetic background : A study of placental alkaline phosphatase = Variabilité interethnique du poids à la naissance et des antécédents génétiques : une étude des phosphates alcalines du placenta

Auteur(s) / Author(s)

AMANTE A. ⁽¹⁾ ; BORGIANI P. ⁽¹⁾ ; GIMELFARB A. ⁽²⁾ ; GLORIA-BOTTINI F. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Cattedra di Pediatria Preventiua e Sociale, Dipartimento di Chirurgia, II Universita di Roma, Tor Vergata, 00173 Rome, ITALIE
⁽²⁾ Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, ETATS-UNIS

Résumé / Abstract

The relationship between human placental alkaline phosphatase (PLAP) genotype and birth weight is investigated in a sample of white, black and Puerto-Rican new-born infants from New Haven, Connecticut (total 710 subjects). Black and Puerto-Rican infants show a higher incidence of growth retardation and a higher frequency of ALPp^*1/^*1 genotype as compared to whites. The proportion of newborns with a low birth weight (below the 10th percentile) is lower in infants with ALPp^*1/^*1 genotype than in those with other PLAP genotypes, especially among non-whites. It is argued that the higher frequency of ALPp^*1 allele among non-whites might be, at least in part, a consequence of their adaptation in the past to environmental conditions adverse to optimal intrauterine development.

Revue / Journal Title

American journal of physical anthropology   ISSN 0002-9483 

Source / Source

1996, vol. 101, n^o4, pp. 449-453 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Liss, New York, NY, ETATS-UNIS  (1918) (Revue)

Mots-clés anglais / English Keywords

North America ; United States of America ; Connecticut ; Puerto Ricans ; American Blacks ; Birth weight ; New-born ; Placenta ; Phenotype ; Genetic differentiation ; Ethnic differentiation ; Adaptation to the environment ; Race ; Population genetics ;

Mots-clés français / French Keywords

Amérique du Nord ; Etats-Unis ; Connecticut ; Portoricains ; Noirs américains ; Poids à la naissance ; Nouveau-né ; Placenta ; Phénotype ; Différenciation génétique ; Différenciation ethnique ; Adaptation à l'environnement ; Race ; Génétique des populations ; Phosphate alcalin ;

Localisation / Location

INIST-CNRS, Cote INIST : 3188, 35400006143839.0010