Titre du document / Document title

A 63bp deletion in the promoter of RAGE correlates with a decreased risk for nephropathy in patients with type 2 diabetes

Auteur(s) / Author(s)

RUDOFSKY G. JR ⁽¹⁾ ; ISERMANN B. ⁽¹⁾ ; SCHILLING T. ⁽¹⁾ ; SCHIEKOFER S. ⁽¹⁾ ; ANDRASSY M. ⁽¹⁾ ; SCHNEIDER J. G. ⁽¹⁾ ; MORCOS M. ⁽¹⁾ ; HUMPERT P. M. ⁽¹⁾ ; SAYED A. A. R. ⁽¹⁾ ; WITTE S. ⁽²⁾ ; RENN W. ⁽³⁾ ; PFOHL M. ^{(3 4)} ; HAMANN A. ⁽¹⁾ ; NOSIKOV V. ⁽⁵⁾ ; SCHLEICHER E. ⁽³⁾ ; HÄRING H.-U. ⁽³⁾ ; SEN G. Rudofsky ⁽⁶⁾ ; RITZ E. ⁽¹⁾ ; NAWROTH P. P. ⁽¹⁾ ; BIERHAUS A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Medicine I, Otto-Meyerhof-Zentrum and Department of Nephrology, University of Heidelberg, ALLEMAGNE
⁽²⁾ Department of Medical Biometry, University of Heidelberg, ALLEMAGNE
⁽³⁾ Department of Medicine IV, University Tübingen, ALLEMAGNE
⁽⁴⁾ Medizinische Klinik I, Bethesda Kliniken zu Duisburg, Duisburg, ALLEMAGNE
⁽⁵⁾ Department of Molecular Diagnostics and Genome Fingerprinting, National Research Center GosNllgenetics, Moscow, RUSSIE, FEDERATION DE
⁽⁶⁾ Department of Angiology, University of Essen, ALLEMAGNE

Résumé / Abstract

Several polymorphisms have been identified in the RAGE-promoter region that might modulate the outcome of disease. Here we analyse the association of a 63bp deletion (delta63) spanning from bp - 407 to bp - 345 with diabetic nephropathy. The deletion was determined using the polymerase chain reaction (PCR) in a cross-sectional study with 1087 patients with type 1 diabetes (n=559) and type 2 diabetes (n=528). 475 patients with osteoporosis served as disease independent control. The prevalence of the heterozygous genotype did not significantly differ between the three groups (type 1: 2.15%, type 2: 2.27%, controls: 1.47%), indicating that heterozygous delta63 is not related to the manifestation of diabetes. Homozygous carriers were not identified in this study. The heterozygous delta63 genotype, was associated with a reduced prevalence of diabetic nephropathy in patients with type 2 diabetes (OR =0.06; 95% Cl: [0.05, 0.07]), but not in patients with type 1 (OR =1.49; 95% CI: [1.14,1.94]). We conclude, that patients with type 2 diabetes and the 63bp deletion in the promoter of RAGE seem to be protected from diabetic nephropathy. The observed difference between type 1 and type 2 diabetes might point to diverse pathomechanisms of nephropathy in both types of diabetes.

Revue / Journal Title

Experimental and clinical endocrinology & diabetes   ISSN 0947-7349 

Source / Source

2004, vol. 112, n^o3, pp. 135-141 [7 page(s) (article)] (56 ref.)

Langue / Language

Anglais

Editeur / Publisher

Thieme , Stuttgart, ALLEMAGNE  (1995) (Revue)

Mots-clés anglais / English Keywords

Endocrinopathy ; Kidney disease ; Urinary system disease ; Nutrition ; Metabolic diseases ; Type 2 diabetes ; Endocrinology ; Human ; Nephropathy ; Risk factor ; Transcription promoter ; Deletion ;

Mots-clés français / French Keywords

Endocrinopathie ; Rein pathologie ; Appareil urinaire pathologie ; Nutrition ; Métabolisme pathologie ; Diabète type 2 ; Endocrinologie ; Homme ; Néphropathie ; Facteur risque ; Promoteur transcription ; Délétion ;

Mots-clés espagnols / Spanish Keywords

Endocrinopatía ; Riñón patología ; Aparato urinario patología ; Nutrición ; Metabolismo patología ; Diabetes de tipo 2 ; Endocrinología ; Hombre ; Nefropatía ; Factor riesgo ; Promotor transcripción ; Deleción ;

Localisation / Location

INIST-CNRS, Cote INIST : 7404, 35400011711679.0040