Titre du document / Document title

Clonidine effects on all-night human sleep: Opposite action of low- and medium-dose clonidine on human NREM-REM sleep proportion

Auteur(s) / Author(s)

MIYAZAKI Shinichi ^{(1 2)} ; UCHIDA Sunao ⁽²⁾ ; MUKAI Junko ^{(1 2)} ; NISHIHARA Kyoko ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Neuropsychiatry, Tokyo Medical and Dental University, Tokyo, JAPON
⁽²⁾ Department of Sleep Disorders Research, Tokyo Institute of Psychiatry, Tokyo, JAPON

Résumé / Abstract

Norepinephrine (NE) is considered to play a permissive role in the occurrence of rapid eye movement (REM) sleep. Clonidine is an NE α-2-receptor agonist, which has been considered to act mainly on the autoreceptors of presynaptic noradrenergic neurons to reduce their release of NE. However, previous studies of clonidine effects on REM sleep have produced controversial results and the effects of clonidine remain uncertain. To clarify the pharmacological effects of clonidine on human sleep, the sleep electroencephalograms (EEG) recorded from 15 young normal subjects after a single administration of either a low (25 μg) or medium (150 μg) dose of clonidine were examined, and fast Fourier transformation (FFT) spectral analyses of the C3-A2 EEG were performed. Low-dose clonidine significantly increased the amount of REM sleep and decreased the amount of non-REM (NREM) sleep during the second one-third of the drug nights compared to the corresponding hours of baseline night recordings. In contrast, medium-dose clonidine significantly decreased REM and increased NREM on drug nights compared to baseline nights in the entire night. The opposite actions of low and medium doses of clonidine on NREM-REM proportion may indicate that low-dose clonidine mainly affects the α-2-receptors on locus coeruleus-NE neurons presynaptically, reducing the release of NE, whereas medium-dose clonidine acts more post-synaptically.

Revue / Journal Title

Psychiatry and clinical neurosciences   ISSN 1323-1316 

Source / Source

2004, vol. 58, n^o2, pp. 138-144 [7 page(s) (article)] (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Richmond, AUSTRALIE  (1995) (Revue)

Mots-clés anglais / English Keywords

Electrodiagnosis ; α-Adrenergic receptor agonist ; Imidazole derivatives ; α2-Adrenergic receptor ; Agonist ; Human ; Young adult ; Male ; Healthy subject ; Sleep ; Rapid eye movement sleep ; Electrophysiology ; Electroencephalography ; Comparative study ; Dose activity relation ; Clonidine ; Biological effect ; Mechanism of action ; Experimental study ;

Mots-clés français / French Keywords

Electrodiagnostic ; Stimulant α-adrénergique ; Imidazole dérivé ; Récepteur α2-adrénergique ; Agoniste ; Homme ; Adulte jeune ; Mâle ; Individu sain ; Sommeil ; Sommeil paradoxal ; Electrophysiologie ; Electroencéphalographie ; Etude comparative ; Relation dose réponse ; Clonidine ; Effet biologique ; Mécanisme action ; Etude expérimentale ;

Mots-clés espagnols / Spanish Keywords

Electrodiagnóstico ; Estimulante α-adrenérgico ; Imidazol derivado ; Receptor α2-adrenérgico ; Agonista ; Hombre ; Adulto joven ; Macho ; Individuo sano ; Sueño ; Sueño paradojal ; Electrofisiología ; Electroencefalografía ; Estudio comparativo ; Relación dosis respuesta ; Clonidina ; Efecto biológico ; Mecanismo acción ; Estudio experimental ;

Localisation / Location

INIST-CNRS, Cote INIST : 2312, 35400011152981.0060