Titre du document / Document title

Risk factors for coronary heart disease in type 1 diabetic patients in Europe: The EURODIAB Prospective complications study

Auteur(s) / Author(s)

EURODIAB Prospective Complications Study Group
SOEDAMAH-MUTHU Sabita S. ⁽¹⁾ ; CHATURVEDI Nish ⁽²⁾ ; TOELLER Monika ⁽³⁾ ; FERRISS Barry ⁽⁴⁾ ; REBOLDI Paolo ⁽⁵⁾ ; MICHEL Georges ⁽⁶⁾ ; MANES Christos ⁽⁷⁾ ; FULLER John H. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Epidemiology and Public-Health, Royal Free and University College London Medical School, London, ROYAUME-UNI
⁽²⁾ International Centre for Circulatory Health and Department of Epidemiology and Public-Health, Imperial College London, London, ROYAUME-UNI
⁽³⁾ Diabetes Research Institute, Heinrich-Heine University, Dusseldorf, ALLEMAGNE
⁽⁴⁾ Cork Regional Hospital, Cork, IRLANDE
⁽⁵⁾ Dipartimento di Medicina Interna e Scienze, Endocrine e Metaboliche, Perugia, ITALIE
⁽⁶⁾ Centre Hospitalier, Luxemburg, LUXEMBOURG
⁽⁷⁾ General Hospital of Thessaloniki, Thessaloniki, GRECE

Résumé / Abstract

OBJECTIVE - The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study. RESEARCH DESIGN AND METHODS- Baseline risk factors and CHD at follow-up were assessed in 2,329 type 1 diabetic patients without prior CHD. CHD was defined as physician-diagnosed myocardial infarction, angina pectoris, coronary artery bypass graft surgery, and/or Minnesota-coded ischemic electrocardiograms or fatal CHD. RESULTS- There were 151 patients who developed CHD, and the 7-year incidence rate was 8.0 (per 1,000 person-years) in men and 10.2 in women. After adjustment for age and/or duration of diabetes, the following risk factors were related to CHD in men: age, GHh, waist-to-hip ratio (WHR), HDL cholesterol, smoking, albumin excretion rate (AER), and autonomic neuropathy. The following risk factors were related to CHD in women: age, systolic blood pressure (BP), fasting triglycerides, AER, and retinopathy Multivariate standardized Cox proportional hazards models showed that age (hazard ratio 1.5), AER (1.3 in men and 1.6 in women), WHR (1.3 in men), smoking (1.5 in men), fasting triglycerides (1.3 in women) or HDL cholesterol (0.74 in women), and systolic BP (1 3 in women) were predictors of CHD. CONCLUSIONS - This study supports the evidence for a strong predictive role of baseline albuminuria in the pathogenesis of CHD in type 1 diabetes. Furthermore, sex-specific risk factors such as systolic BP, fasting triglycerides (or HDL cholesterol), and WHR were found to be important in the development of CHD.

Revue / Journal Title

Diabetes care   ISSN 0149-5992   CODEN DICAD2 

Source / Source

2004, vol. 27, n^o2, pp. 530-537 [8 page(s) (article)] (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Diabetes Association, Alexandria, VA, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Autoimmune disease ; Immunopathology ; Endocrinopathy ; Cardiovascular disease ; Complication ; Europe ; Public health ; Type 1 diabetes ; Human ; Risk factor ; Coronary heart disease ;

Mots-clés français / French Keywords

Maladie autoimmune ; Immunopathologie ; Endocrinopathie ; Appareil circulatoire pathologie ; Complication ; Europe ; Santé publique ; Diabète type 1 ; Homme ; Facteur risque ; Cardiopathie coronaire ;

Mots-clés espagnols / Spanish Keywords

Enfermedad autoinmune ; Inmunopatología ; Endocrinopatía ; Aparato circulatorio patología ; Complicación ; Europa ; Salud pública ; Diabetes de tipo 1 ; Hombre ; Factor riesgo ; Cardiopatía coronaria ;

Localisation / Location

INIST-CNRS, Cote INIST : 18054, 35400011350254.0380