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Titre du document / Document title

Cancer chemopreventive activity of rotenoids from Derris trifoliata

Auteur(s) / Author(s)

ITO Chihiro (1) ; ITOIGAWA Masataka (2) ; KOJIMA Naoki (1) ; TAN Hugh T.-W. (3) ; TAKAYASU Junko (4) ; TOKUDA Harukuni (4) ; NISHINO Hoyoku (4) ; FURUKAWA Hiroshi (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Faculty of Pharmacy, Meijo University, Nagoya, JAPON
(2) Tokai Gakuen University, Aichi, JAPON
(3) Department of Botany, National University of Singapore, SINGAPOUR
(4) Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, JAPON

Résumé / Abstract

A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aα,12aα-12a-hydroxyelliptone (3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of β-carotene without any cytotoxicity. Deguelin (4) and α-toxicarol (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.

Revue / Journal Title

Planta medica    ISSN  0032-0943   CODEN PLMEAA 

Source / Source

2004, vol. 70, no1, pp. 8-11 [4 page(s) (article)] (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1953) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Mouse

;

Animal

;

Epstein Barr virus

;

In vitro

;

Screening test

;

Screening

;

Identification

;

Isolation

;

Leguminosae

;

Stem

;

Antitumor promotor

;

Prevention

;

Malignant tumor

;

Anticarcinogen

;

Medicinal plant

;

Plant origin

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Derris trifoliata

;

Rotenoides

;

Souris

;

Animal

;

Phorbol 13-acétate 12-myristate

;

Virus Epstein Barr

;

In vitro

;

Test activité

;

Criblage

;

Identification

;

Isolement

;

Leguminosae

;

Tige

;

Antipromoteur tumeur

;

Prévention

;

Tumeur maligne

;

Anticarcinogène

;

Plante médicinale

;

Origine végétale

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Ratón

;

Animal

;

Epstein Barr virus

;

In vitro

;

Prueba actividad

;

Cernido

;

Identificación

;

Aislamiento

;

Leguminosae

;

Tallo

;

Antitumoral promotor

;

Prevención

;

Tumor maligno

;

Anticarcinógeno

;

Planta medicinal

;

Origen vegetal

;

Mots-clés d'auteur / Author Keywords

Derris trifoliata

;

Leguminosae

;

rotenoid

;

cancer chemopreventive agents

;

anti-tumor promoters

;

Localisation / Location

INIST-CNRS, Cote INIST : 9624, 35400011666626.0020

Nº notice refdoc (ud4) : 15502257



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