Titre du document / Document title

Electro-acupuncture reverses nerve growth factor abundance in experimental polycystic ovaries in the rat

Auteur(s) / Author(s)

YOUNG HOON BAI ⁽¹⁾ ; SUNG CHUL LIM ⁽²⁾ ; CHANG HUN SONG ⁽³⁾ ; CHUN SIK BAE ⁽⁴⁾ ; CHEON SIK JIN ⁽⁵⁾ ; BUM CHAE CHOI ⁽⁶⁾ ; CHUL HO JANG ⁽⁷⁾ ; SEUNG HOO LEE ⁽⁸⁾ ; SOK CHEON PAK ⁽⁸⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Research Division of Biological Science, Chosun University Medical School, Gwangju, COREE, REPUBLIQUE DE
⁽²⁾ Department of Pathology and Research Center for Resistant Cells,, Chosun University Medical School, Gwangju, COREE, REPUBLIQUE DE
⁽³⁾ Department of Obstetrics and Gynecology, Chosun University Medical School, Gwangju, COREE, REPUBLIQUE DE
⁽⁴⁾ College of Veterinary Medicine, Chonnam National University, Gwangju, COREE, REPUBLIQUE DE
⁽⁵⁾ Cheon Sik Jin Oriental Medical Clinic, Cheongju, COREE, REPUBLIQUE DE
⁽⁶⁾ Creation and Love Women's Hospital, Gwangju, COREE, REPUBLIQUE DE
⁽⁷⁾ Department of Otolaryngology, Wonkwang University Medical School, Iksan, COREE, REPUBLIQUE DE
⁽⁸⁾ Hamilton College of Oriental Medicine, Hamilton, NOUVELLE-ZELANDE

Résumé / Abstract

Polycystic ovary syndrome (PCOS) remains one of the most common causes of anovulation in women of reproductive age. There is some evidence that nerve growth factor (NGF) is involved in the pathogenesis of PCOS. Therefore, seeking the pathogenesis of PCOS is important for controlling fertility. In traditional Oriental Medicine, acupuncture has been used for the function of ovaries. The present study was designed to determine whether electro-acupuncture (EA) could affect experimentally induced polycystic ovary (PCO) in the rat. The two acupoints Sp-6 and E-128 were stimulated to test for efficacy in the protein expression of NGF. Polycystic ovaries were induced by a single injection of estradiol valerate (4 mg i.m.). During the experimental period of 8 weeks, some of the rats were treated with EA twice weekly; this group was compared with a vehicle-treated control group and an estradiol-injected group not subjected to EA. At day 60, the protein expression of NGF was examined by immunohistochemistry in the ovaries, the adrenal glands and some parts of the brain. The estradiol treatment induced a clear PCO appearance, and was associated with a robust increase in NGF expression in the ovaries, the adrenal glands and the brain. EA treatment partly reversed the NGF abundance, particularly in the ovaries, but not in the brain. Our data show that EA affects the NGF involvement in ovarian dysfunction.

Revue / Journal Title

Gynecologic and obstetric investigation   ISSN 0378-7346   CODEN GOBIDS 

Source / Source

2004, vol. 57, n^o2, pp. 80-85 [6 page(s) (article)] (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Karger, Basel, SUISSE  (1978) (Revue)

Mots-clés anglais / English Keywords

Anatomic pathology ; Female sterility ; Cyst ; Benign neoplasm ; Ovarian diseases ; Female genital diseases ; Folk medicine ; Oriental medicine ; Vertebrata ; Mammalia ; Rodentia ; Treatment ; Immunohistochemistry ; Obstetrics ; Estradiol valerate ; Gynecology ; Rat ; Polycystic ovary ; Animal ; Nerve growth factor ; Acupuncture ;

Mots-clés français / French Keywords

Anatomopathologie ; Stérilité femelle ; Kyste ; Tumeur bénigne ; Ovaire pathologie ; Appareil génital femelle pathologie ; Médecine traditionnelle ; Médecine orientale ; Vertebrata ; Mammalia ; Rodentia ; Traitement ; Immunohistochimie ; Obstétrique ; Valérate d'estradiol ; Gynécologie ; Rat ; Ovaire polykystique ; Animal ; Facteur croissance nerf ; Acupuncture ;

Mots-clés espagnols / Spanish Keywords

Anatomía patológica ; Esterilidad femenina ; Quiste ; Tumor benigno ; Ovario patología ; Aparato genital hembra patología ; Medicina tradicional ; Medicina oriental ; Vertebrata ; Mammalia ; Rodentia ; Tratamiento ; Inmunohistoquímica ; Obstétrico ; Valerato de estradiol ; Ginecología ; Rata ; Ovario poliquístico ; Animal ; Factor crecimiento nervio ; Acupuntura ;

Mots-clés d'auteur / Author Keywords

Electro-acupuncture ; Polycystic ovary syndrome ; Nerve growth factor ; Estradiol valerate ; Immunohistochemistry ;

Localisation / Location

INIST-CNRS, Cote INIST : 4172, 35400011915791.0040