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Titre du document / Document title

Diabetes tipo 2: gluco-lipo-toxicidad y disfunciÓn de la célula β pancreática = Type 2 diabetes: gluco-lipo-toxicity and pancreatic β-cell dysfunction

Auteur(s) / Author(s)

ROCHE E. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) DivisiÓn de NutriciÓn, Departamento de Biología Aplicada. Universidad Miguel Hernández, 03550-Sant Joan (Alicante), ESPAGNE

Résumé / Abstract

The pancreatic β-cell secretes insulin according to extracellular glucose concentration. Other nutrients, such as fatty acids, are also implicated in the secretory process. This could be defined as a normal physiological adaptation of hormone secretion to extracellular demand. However, this secretory pattern is abolished in chronic hyperglycemic and hyperlipidemic conditions, typical of diabetic pathology. Experimental evidence directly correlates the sustained concentrations of these nutrients with the development of the disease. In this phenomenon, known as glucotoxicity, when glucose alters β cell function, and lipotoxicity for fatty acids, the nutrients affect various gene programs, leading to key phenotypic changes in the β-cell. In order to maintain a correct secretory response, β-cells possess mechanisms to adapt and detoxify the excess of nutrients. However, programmed cell death occurs when sustained hyperglycemia and hyperlipidemia appear simultaneously. This situation culminates in cell loss, lack of insulin and overt diabetes.

Revue / Journal Title

Ars pharmaceutica    ISSN  0004-2927 

Source / Source

2003, vol. 44, no4, pp. 313-332 [20 page(s) (article)] (53 ref.)

Langue / Language

Revue : Espagnol

Editeur / Publisher

Universidad de Granada, Facultad de Farmacia, Granada, ESPAGNE  (1960) (Revue)

Mots-clés anglais / English Keywords



Mots-clés français / French Keywords



Mots-clés espagnols / Spanish Keywords



Localisation / Location

INIST-CNRS, Cote INIST : 9430, 35400011595411.0010

Nº notice refdoc (ud4) : 15431208

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