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Titre du document / Document title

Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation

Auteur(s) / Author(s)

IWATSUKI Kenji (1) ; AKIHISA Toshihiro (2) ; TOKUDA Harukuni (3) ; UKIYA Motohiko (2) ; OSHIKUBO Manabu (2) ; KIMURA Yumiko (4) ; ASANO Takeshi (5) ; NOMURA Atsushi (1) ; NISHINO Hoyoku (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) K-Laboratories for Intelligent Medical Remote Services, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, JAPON
(2) College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, JAPON
(3) Department of Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, JAPON
(4) College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, JAPON
(5) Department of Orthopaedics, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, JAPON

Résumé / Abstract

A new triterpene acid, lucidenic acid P (la), and two new triterpene acid methyl esters, methyl lucidenates P (1b) and Q (2b), were isolated and characterized from the fruiting body of the fungus Ganoderma lucidum. Their structures were elucidated on the basis of spectroscopic methods. In addition, eight known triterpene acids, lucidenic acids A (3a), C (4a), D2 (5a), E2 (6a), and F (7a) and ganoderic acids E (9a), F (lOa), and T-Q (lla), and six known triterpene acid methyl esters, methyl lucidenates A (3b), D2 (5b), E2 (6b), F (7b), and L (8b) and methyl ganoderate F (lOb), were isolated and identified from the fungus. All of the triterpenoids, with the exception of 7a, were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor promoters. All of the compounds tested showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 x 103 mol ratio/TPA).

Revue / Journal Title

Journal of natural products    ISSN  0163-3864   CODEN JNPRDF 

Source / Source

2003, vol. 66, no12, pp. 1582-1585 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

American Society of Pharmacognosy, Northbrook, IL, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Infection

;

Viral disease

;

Asia

;

Thallophyta

;

Fungi

;

Basidiomycetes

;

Early antigen

;

Epstein Barr virus

;

Inhibition

;

Burkitt lymphoma

;

Human

;

Cell line

;

In vitro

;

Antitumor promotor

;

Anticarcinogen

;

Screening test

;

Biological activity

;

Triterpene

;

Terpenoid

;

Structural analysis

;

China

;

Folk medicine

;

Pharmacognosy

;

Medicinal plant

;

Ganoderma

;

Plant origin

;

Isolation

;

Mots-clés français / French Keywords

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Infection

;

Virose

;

Asie

;

Thallophyta

;

Fungi

;

Basidiomycetes

;

Lignée RAJI

;

25,26,27-Trinorlanost-8-én-24-oïque acide(7β,15α-dihydroxy-3,11-dioxo) ester méthyle

;

Lucidénique acide P

;

25,26,27-Trinorlanost-8-én-24-oïque acide(12β-acétoxy-3β,7β-dihydroxy-11,15-dioxo) ester méthyle

;

Lanostane dérivé

;

Ganoderma lucidum

;

Antigène précoce

;

Virus Epstein Barr

;

Inhibition

;

Lymphome Burkitt

;

Homme

;

Lignée cellulaire

;

In vitro

;

Antipromoteur tumeur

;

Anticarcinogène

;

Test activité

;

Activité biologique

;

Triterpène

;

Terpénoïde

;

Analyse structurale

;

Chine

;

Médecine traditionnelle

;

Pharmacognosie

;

Plante médicinale

;

Ganoderma

;

Origine végétale

;

Isolement

;

Mots-clés espagnols / Spanish Keywords

Virus

;

Herpesviridae

;

Gammaherpesvirinae

;

Infección

;

Virosis

;

Asia

;

Thallophyta

;

Fungi

;

Basidiomycetes

;

Antígeno precoz

;

Epstein Barr virus

;

Inhibición

;

Linfoma Burkitt

;

Hombre

;

Línea celular

;

In vitro

;

Antitumoral promotor

;

Anticarcinógeno

;

Prueba actividad

;

Actividad biológica

;

Triterpeno

;

Terpenoide

;

Análisis estructural

;

China

;

Medicina tradicional

;

Farmacognosia

;

Planta medicinal

;

Ganoderma

;

Origen vegetal

;

Aislamiento

;

Localisation / Location

INIST-CNRS, Cote INIST : 4127, 35400011905040.0130

Nº notice refdoc (ud4) : 15384729



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