Titre du document / Document title

Comparison of oral azithromycin pulse with daily doxycycline in the treatment of acne vulgaris

Auteur(s) / Author(s)

SINGHI M. K. ⁽¹⁾ ; GHIYA B. C. ⁽¹⁾ ; DHABHAL R. K. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departments of Skin, V.D. & Leprosy, Dr. S. N. Medical College, Jodhpur, INDE

Résumé / Abstract

Introduction: Oral azithromycin has been advocated by some in the treatment of acne. However, its efficacy has not been established. Material and Methods: This non-randomized controlled trial was conducted on 70 outpatients with acne vulgaris to compare the efficacy and safety of azithromycin and doxycycline in the treatment of inflammatory acne. In the first group, azithromycin was administered 500 mg daily before meals for 3 consecutive days in a 10-day cycle, with the remaining seven days in each cycle being drug-free days. The second group was given doxycycline 100 mg daily after meals. Topical erythromycin was prescribed to all patients. Clinical assessment was done at 10-day intervals for both the groups up to three months. We followed the severity index described by Michaelsson for assessment of outcome measures. Results: There was 77.26% improvement in azithromycin treated group in comparison to 63.74% in the doxycycline treated group. There was a statistically significant reduction in severity in the azithromycin treated group. Conclusion: The study showed that a combination of azithromycin with topical erythromycin was significantly better than doxycycline with topical erythromycin in the treatment of acne vulgaris. The incidence and severity of side effects were also lower with azithromycin.

Revue / Journal Title

Indian Journal of Dermatology Venereology and Leprology   ISSN 0378-6323   CODEN IJDLDY 

Source / Source

2003, vol. 69, n^o4, pp. 274-276 [3 page(s) (article)] (8 ref.)

Langue / Language

Anglais

Editeur / Publisher

Indian Association of Dermatologists, Venereologists and Leprologists, New Delhi, INDE  (1976) (Revue)

Mots-clés anglais / English Keywords

Skin disease ; Asia ; Tetracycline derivatives ; Antibiotic ; Antibacterial agent ; Macrolide ; India ; Human ; Oral administration ; Tropical medicine ; Dermatology ; Treatment ; Doxycycline ; Chemotherapy ; Azithromycin ; Comparative study ; Acne vulgaris ;

Mots-clés français / French Keywords

Peau pathologie ; Asie ; Tétracycline dérivé ; Antibiotique ; Antibactérien ; Macrolide ; Inde ; Homme ; Voie orale ; Médecine tropicale ; Dermatologie ; Traitement ; Doxycycline ; Chimiothérapie ; Azithromycine ; Etude comparative ; Acné vulgaire ;

Mots-clés espagnols / Spanish Keywords

Piel patología ; Asia ; Tetraciclina derivado ; Antibiótico ; Antibacteriano ; Macrólido ; India ; Hombre ; Vía oral ; Medicina tropical ; Dermatología ; Tratamiento ; Doxiciclina ; Quimioterapia ; Azitromicina ; Estudio comparativo ; Acné vulgar ;

Mots-clés d'auteur / Author Keywords

Azithromycin ; Acne Vulgaris ; Doxycycline ;

Localisation / Location

INIST-CNRS, Cote INIST : 2367, 35400011639797.0030