Titre du document / Document title

Insulin sensitivity and hemostatic factors in clinically healthy 58-year-old men

Auteur(s) / Author(s)

AGEWALL Stefan ⁽¹⁾ ; BOKEMARK Lena ⁽²⁾ ; WIKSTRAND John ⁽³⁾ ; LINDAHL Anders ⁽⁴⁾ ; FAGERBERG Björn ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Cardiology, Sahlgrenska University Hospital, Göteborg University, SUEDE
⁽²⁾ Department of Medicine, Sahlgrenska University Hospital, Göteborg University, SUEDE
⁽³⁾ Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, SUEDE
⁽⁴⁾ Department of Clinical Chemistry, Sahlgrenska University Hospital, Göteborg University, SUEDE

Résumé / Abstract

The objective of this cross-sectional study was to investigate the relationship between factors of the coagulation- and fibrinolysis systems and insulin sensitivity in 104 clinically healthy, 58-years-old men. Insulin sensitivity (hyperinsulinemic euglycemic clamp) adjusted for lean body mass, the metabolic syndrome according to a suggested definition, and different factors in the coagulation- and fibrinolysis system were determined. Subjects with the metabolic syndrome were characterised by increases in PAI-1 activity, tPA antigen, protein C and protein S and low concentrations of tPA activity. Insulin sensitivity was independently and reversibly associated with PAI-I (p = 0.014) and directly with tPA activity (p = 0.001). Insulin sensitivity was also significantly negatively associated with protein S and protein C and several components in the metabolic syndrome, however not remaining significant in multivariate analyses. Protein C and protein S were significantly associated with PAI-I activity, tPA activity (negatively), tPA antigen and antithrombin III. In conclusion, the data indicated that insulin resistance and several of the clustering components in the metabolic syndrome are accompanied by increased plasma concentrations of the anticoagulatory proteins C and S which may represent a mechanism which counteracts the concomitantly occurring hypofibrinolysis.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

2000, vol. 84, n^o4, pp. 571-575 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Atherosclerosis ; Thrombosis ; Insulin ; Sensitivity ; Hemostasis ; Blood coagulation ; Fibrinolysis ; Risk factor ; Adult ; Male ; Healthy subject ; Human ; Cardiovascular disease ; Vascular disease ; Pancreatic hormone ; Protein hormone ;

Mots-clés français / French Keywords

Athérosclérose ; Thrombose ; Insuline ; Sensibilité ; Hémostase ; Coagulation sanguine ; Fibrinolyse ; Facteur risque ; Adulte ; Mâle ; Individu sain ; Homme ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ; Hormone pancréatique ; Hormone protéine ;

Mots-clés espagnols / Spanish Keywords

Ateroesclerosis ; Trombosis ; Insulina ; Sensibilidad ; Hemostasis ; Coagulación sanguínea ; Fibrinólisis ; Factor riesgo ; Adulto ; Macho ; Individuo sano ; Hombre ; Aparato circulatorio patología ; Vaso sanguíneo patología ; Hormona pancreática ; Hormona proteina ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400009253601.0090