Titre du document / Document title
Spectrophotometric methods for the determination of ebastine in tablets
Auteur(s) / Author(s)SUNITHA P. G.
Résumé / Abstract
A simple and precise second derivative UV spectrophotometric method (A) and colorimetric method (B) were developed for the estimation of ebastine in pharmaceutical dosage form. The λmax
of ebastine is found to be 253nm. The second derivative spectrum shows well resolved trough from excipients. Colorimetry is based on the formation of orange-red coloured chromogen with formaldehyde and concentrated sulphuric acid which has absorption maximum at 537 nm. Linearity for these methods lie in the concentration range of 4-24 mcg/ml and 20-100 mcg/ml respectively. The proposed methods are sensitive, accurate, reproducible and useful for the routine determination of ebastine in tablets.
Revue / Journal TitleIndian drugs
Source / Source
2003, vol. 40, no
10, pp. 577-579 [3 page(s) (article)]
Langue / Language
Editeur / Publisher
Indian Drug Manufacturers' Association, Bombay, INDE
Localisation / Location
INIST-CNRS, Cote INIST : 19200, 35400011881316.0050
Nº notice refdoc (ud4) : 15312760