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Titre du document / Document title

Spectrophotometric methods for the determination of ebastine in tablets

Auteur(s) / Author(s)

SUNITHA P. G. ; NIRALMATHI V. ; ARUNA A. ; VAIDHYALINGAM V. ; SHANTHA A. ;

Résumé / Abstract

A simple and precise second derivative UV spectrophotometric method (A) and colorimetric method (B) were developed for the estimation of ebastine in pharmaceutical dosage form. The λmax of ebastine is found to be 253nm. The second derivative spectrum shows well resolved trough from excipients. Colorimetry is based on the formation of orange-red coloured chromogen with formaldehyde and concentrated sulphuric acid which has absorption maximum at 537 nm. Linearity for these methods lie in the concentration range of 4-24 mcg/ml and 20-100 mcg/ml respectively. The proposed methods are sensitive, accurate, reproducible and useful for the routine determination of ebastine in tablets.

Revue / Journal Title

Indian drugs    ISSN  0019-462X   CODEN INDRBA 

Source / Source

2003, vol. 40, no10, pp. 577-579 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Indian Drug Manufacturers' Association, Bombay, INDE  (1963) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 19200, 35400011881316.0050

Nº notice refdoc (ud4) : 15312760



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