Titre du document / Document title

Oral misoprostol (100 μg) versus vaginal misoprostol (25 μg) in term labor induction: a randomized comparison

Auteur(s) / Author(s)

SHETTY Ashalatha ⁽¹⁾ ; LIVINGSTONE Iona ⁽²⁾ ; ACHARYA Santanu ⁽¹⁾ ; RICE Pat ⁽¹⁾ ; DANIELIAN Peter ⁽¹⁾ ; TEMPLETON Allan ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics and Gynecology, Aberdeen Maternity Hospital, Aberdeen, Scotland, ROYAUME-UNI
⁽²⁾ University of Aberdeen Medical School, Foresterhill, Aberdeen, Scotland, ROYAUME-UNI

Résumé / Abstract

Objective. To compare the efficacy of vaginal misoprostol (25 μg) to oral misoprostol (100 μg) in labor induction at term. Methods. One hundred and one women at term, with indications for labor induction and cervical Bishop's scores of less than 8, were randomly assigned to receive 100 μg of oral misoprostol or 25 μg vaginal misoprostol after random allocation. This could be repeated every 4h to a maximum of five doses. The number delivering vaginally within 24 h of the induction was the main outcome measure. Results. Of those who delivered vaginally (74.5% in the oral group vs. 72% in the vaginal group), significantly fewer women delivered within 24 h of induction in the oral group (42.1% vs. 72.2%, RR0.6, 95% CI 0.4-0.9), with more women receiving more than one dose (45.7% vs. 16.7%, RR 2.7, 95% CI 1.2-6.0). More women in the oral group received oxytocin (68.6% vs. 44%, RR 1.6, 95% CI 1.1-2.2), and the induction to delivery interval was shorter in the vaginal group, although this was not statistically significant [28.9 h (SD 20.2) vs. 20.6 h (SD 16.1), mean difference - 8.3 h, 95% CI - 16.8 to 0.2]. There were no differences in the modes of delivery, uterine hyperstimulation rates or in the neonatal outcomes. Conclusion. Vaginal misoprostol in its currently recommended dose of 25 μg seems to be more efficacious than the 100 μg oral dose.

Revue / Journal Title

Acta obstetricia et gynecologica Scandinavica   ISSN 0001-6349   CODEN AOGSAE 

Source / Source

2003, vol. 82, n^o12, pp. 1103-1106 [4 page(s) (article)] (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1925) (Revue)

Mots-clés anglais / English Keywords

Oxytocic ; Inducer ; Antiulcer agent ; Antisecretory agent ; Prostaglandin derivatives ; Comparative study ; Female ; Human ; Effective dose ; Analysis ; Randomization ; Induction ; Labor ; Vaginal route ; Oral administration ; Chemotherapy ; Misoprostol ;

Mots-clés français / French Keywords

Ocytocique ; Inducteur ; Antiulcéreux ; Antisécrétoire ; Prostaglandine dérivé ; Etude comparative ; Femelle ; Homme ; Dose efficace ; Analyse ; Randomisation ; Induction ; Travail obstétrical ; Voie vaginale ; Voie orale ; Chimiothérapie ; Misoprostol ;

Mots-clés espagnols / Spanish Keywords

Ocitócico ; Inductor ; Antiulceroso ; Antisecretorio ; Prostaglandina derivado ; Estudio comparativo ; Hembra ; Hombre ; Dosis eficaz ; Análisis ; Aleatorización ; Inducción ; Trabajo de parto ; Vía vaginal ; Vía oral ; Quimioterapia ; Misoprostol ;

Mots-clés d'auteur / Author Keywords

oral misoprostol ; vaginal misoprostol ; labor induction at term ;

Localisation / Location

INIST-CNRS, Cote INIST : 964 A, 35400011487817.0070