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Titre du document / Document title

Hepatoprotective activity of panchagavya ghrita against carbontetrachloride induced hepatotoxicity in rats

Auteur(s) / Author(s)

ACHLIYA G. S. ; KOTAGALE N. R. ; WADODKAR S. G. ; DORLE A. K. ;

Résumé / Abstract

Objective: To investigate the hepatoprotective activity of Panchagavya Ghrita (PG) against CCl4 induced hepatotoxicity. Methods: The hepatoprotective activity of PG was tested against carbontetrachloride induced hepatotoxicity in albino rats. The degree of protection was determined by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT) serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and acid phosphatase (ACP).The histological studies were also carried out. Silymarin was used as the standard drug for comparison. Results: Administration of Panchagavya Ghrita (150-300 mg/kg, p.o.) markedly prevented CCl4 induced elevation of levels of serum GPT, GOT, ACP and ALP. The results are comparable to that of silymarin. A comparative histopathological study of liver exhibited almost normal architecture, as compared to control group. Conclusion: Treatment with Panchagavya Ghrita significantly reduced the CCI4 induced hepatotoxicity. A comparative histological study of liver from different groups further confirmed the hepatoprotective activity of Panchagavya Ghrita.

Revue / Journal Title

Indian journal of pharmacology    ISSN  0253-7613 

Source / Source

2003, vol. 35, no5, pp. 308-311 [4 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Indian Pharmacological Society, Pondicherry, INDE  (1969) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 21749, 35400011339901.0050

Nº notice refdoc (ud4) : 15240774



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