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Titre du document / Document title

Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function

Auteur(s) / Author(s)

PARK Gordon Jung-Hyuk (1) ; KATELARIS Peter Harry (1) ; JONES D. Brian (1) ; SEOW Francis (1) ; LE COUTEUR David George (2) ; MENG CHONG NGU (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Gastroenterology and Hepatology, The University of Sydney, Concord Hospital, Concord, NSW, AUSTRALIE
(2) Centre for Education and Research on Aging, The University of Sydney, Concord Hospital, Concord, NSW, AUSTRALIE

Résumé / Abstract

The properties of caffeine render it an ideal substrate for a quantitative test of liver function. The aim of this study was to determine whether the caffeine breath test (CBT) using orally administered 13C-caffeine correlates reliably with plasma caffeine clearance and reflects varying degrees of liver dysfunction. The CBT was performed in 25 healthy controls; 20 subjects with noncirrhotic, chronic hepatitis B or C; and 20 subjects with cirrhosis. Plasma caffeine clearance was assayed simultaneously with the CBT in a cohort of these subjects. Over a broad range of caffeine clearances, the CBT exhibited a highly significant correlation with plasma clearance (r = 0.85, P <.001). Cirrhotic patients were characterized by significantly reduced CBT values (1.15 ± 0.75 Δ‰ mg-1) compared with controls (2.23 ± 0.76; P =.001) and hepatitic patients (1.83 ± 1.05; P =.04). There was a significant inverse relationship between the CBT and Child-Pugh score (r = -.74, P =.002). The intraclass correlation coefficient between repeated CBTs in 20 subjects with normal and cirrhotic livers was 0.89. Although smoking was associated with an 86% to 141% increase in CBT in all groups, the CBT was able to distinguish control, hepatitic, and cirrhotic smokers (5.36 ± 0.82, 3.63 ± 1.21, and 2.14 ± 1.14, respectively, P =.001). Multivariate analysis revealed that only smoking (P <.001) and disease state (P =.001) were significant predictors of the CBT. In conclusion, the 13C-CBT represents a valid indicator of plasma caffeine clearance and correlates reproducibly with hepatic dysfunction.

Revue / Journal Title

Hepatology    ISSN  0270-9139   CODEN HPTLD9 

Source / Source

2003, vol. 38, no5, pp. 1227-1236 [10 page(s) (article)] (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Radionuclide study

;

Hepatic disease

;

Digestive diseases

;

Oceania

;

Infection

;

Viral disease

;

Australia

;

Human

;

Performance evaluation

;

Quantitative analysis

;

Caffeine

;

Breath test

;

Non invasive method

;

Liver function

;

Functional analysis

;

Chronic

;

Viral hepatitis

;

Mots-clés français / French Keywords

Exploration radioisotopique

;

Foie pathologie

;

Appareil digestif pathologie

;

Océanie

;

Infection

;

Virose

;

Australie

;

Homme

;

Evaluation performance

;

Analyse quantitative

;

Caféine

;

Test respiratoire

;

Méthode non invasive

;

Fonction hépatique

;

Analyse fonctionnelle

;

Chronique

;

Hépatite virale

;

Mots-clés espagnols / Spanish Keywords

Exploración radioisotópica

;

Hígado patología

;

Aparato digestivo patología

;

Oceania

;

Infección

;

Virosis

;

Australia

;

Hombre

;

Evaluación prestación

;

Análisis cuantitativo

;

Cafeína

;

Test respiratorio

;

Método no invasivo

;

Función hepática

;

Análisis funcional

;

Crónico

;

Hepatitis vírica

;

Localisation / Location

INIST-CNRS, Cote INIST : 19427, 35400011864734.0180

Nº notice refdoc (ud4) : 15240498



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