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Titre du document / Document title

Inhibition of nicotine-DNA adduct formation in mice by six dietary constituents

Auteur(s) / Author(s)

CHENG Y. (1) ; LI H. L. (1) ; WANG H. F. (1) ; SUN H. F. (1) ; LIU Y. F. (1) ; PENG S. X. (2) ; LIU K. X. (2) ; GUO Z. Y. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Applied Chemistry and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, CHINE
(2) Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing 100871, CHINE

Résumé / Abstract

Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine] is a major alkaloid in tobacco products and has proven to be a potential genotoxic compound. Many natural dietary products can suppress the DNA adduction, and hence act as inhibitors of cancer. In this study, we investigated the inhibitory effects of curcumin, garlic squeeze, grapeseed extract, tea polyphenols, vitamin C, and vitamin E on nicotine-DNA adduction in vivo using an ultrasensitive method of accelerator mass spectrometry (AMS). The results demonstrated that all the dietary constituents induced marked dose-dependent decrease in nicotine-DNA adducts as compared with the control. The reduction rate reached about 50% for all agents, except garlic squeeze (40%), even at its highest dose level. Amongst the six agents, grapeseed extract exhibited the strongest inhibition to the DNA adduct formation. Therefore, we may arrive at a point that these dietary constituents are beneficial to prevent the harmful adduct formation, and thus to block the potential carcinogenesis induced by nicotine.

Revue / Journal Title

Food and chemical toxicology    ISSN  0278-6915   CODEN FCTOD7 

Source / Source

2003, vol. 41, no7, pp. 1045-1050 [6 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Oxford, ROYAUME-UNI  (1982) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Toxicity

;

Food

;

E-Vitamins

;

Ascorbic acid

;

Tea

;

Grapeseed oil

;

Garlic

;

Curcumin

;

Anticarcinogen

;

Comparative study

;

Animal

;

Mouse

;

DNA

;

Molecular adduct

;

Genotoxicity

;

Nicotine

;

Tobacco

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Toxicité

;

Aliment

;

Vitamine E

;

Acide ascorbique

;

Thé

;

Huile pépin raisin

;

Ail

;

Curcumine

;

Anticarcinogène

;

Etude comparative

;

Animal

;

Souris

;

DNA

;

Adduit moléculaire

;

Génotoxicité

;

Nicotine

;

Tabac

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Toxicidad

;

Alimento

;

Vitamina E

;

Acido ascórbico

;

;

Aceite semilla uva

;

Ajo

;

Curcumina

;

Anticarcinógeno

;

Estudio comparativo

;

Animal

;

Ratón

;

DNA

;

Producto adición molecular

;

Genotoxicidad

;

Nicotina

;

Tabaco

;

Mots-clés d'auteur / Author Keywords

Inhibition

;

Dietary constituents

;

Nicotine

;

DNA adducts

;

AMS

;

Localisation / Location

INIST-CNRS, Cote INIST : 10616, 35400011332955.0150

Nº notice refdoc (ud4) : 15219956



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